碘对比剂诱发甲状腺功能减退的病因及临床特点研究进展

Research progress on etiology and clinical characteristics of ICM-induced hypothyroidism

应用碘对比剂(ICM)可诱发甲状腺功能减退(IIHypo)。新近研究发现ICM可独立于游离碘而特异性抑制甲状腺对碘化物摄取,其作用机制与传统的Wolff-Chaikoff效应并不一致。目前关于IIHypo发病率、相关危险因素及监测ICM诱发事件的适应证等问题尚未完全确定。认识发生IIHypo的潜在风险因素、及时评估在碘暴露时间窗内发生的碘诱导事件,对优化ICM诱发甲状腺功能障碍诊断和管理程序具有重要临床意义。

Iodinated contrast media(ICM)administration may induce hypothyroidism(IIHypo).Recent studies have found that ICM can specifically inhibit thyroid iodide uptake by iodide independently of free iodide through a mechanism different from the conventional Wolff-Chaikoff effect.At present,issues regarding the incidence of IIHypo,related risk factors and indications for monitoring ICM-induced events have not been fully determined.Recognizing of potential risk factors for IIHypo and timely assessment of iodine-induced events within the time window of iodine exposure have important clinical significance for optimizing the diagnosis and management procedures of ICM-induced thyroid dysfunction.