急性缺血性卒中血管再通治疗后早期神经功能恶化研究进展

Research progress on early neurological deterioration after vascular recanalization in acute ischemic stroke

血管再通治疗已成为急性缺血性卒中(AIS)的有效治疗方法,但由于出血转化、不良再灌注、血管再闭塞等各种因素的影响,有部分AIS患者在接受血管再通治疗后会出现早期神经功能恶化(END),主要表现为病情进展、神经功能损伤加重,严重影响患者预后。目前END尚无统一的名称及诊断标准,有关再通治疗后END的研究结果亦不尽相同。就再通治疗后END发病机制、危险因素以及预测因子等相关内容进行综述。

Recanalization therapy has become an effective treatment for acute ischemic stroke(AIS),but due to the influence of various factors such as bleeding transformation,poor reperfusion and vascular reocclusion,some AIS patients will experience early neurological deterioration(END)after recanalization therapy,which is mainly manifested as disease progression and aggravated neurological impairment,seriously affecting the prognosis of patients.At present,there is no uniform name and diagnostic criteria for END,and results of studies on END after recanalization therapy are also different.This article reviews the pathogenesis,risk factors and predictors of END after recanalization therapy.