M2型巨噬细胞极化及其对动脉粥样硬化的影响

M2 macrophage polarization and its impact on atherosclerosis

动脉粥样硬化是心血管疾病的重要发病原因,其患病率逐年增高,带来了庞大的经济和社会负担。近年来,人们逐渐发现M2型巨噬细胞在动脉粥样硬化病变消退的过程中扮演着重要的角色,它可以释放多种抗炎因子、促进胞葬作用和组织修复等。通过M2型巨噬细胞或可取得新的治疗进展。本文将对M2型巨噬细胞的起源与分型、极化过程及其与动脉粥样硬化病变消退之间的关系进行概述。

As the underlying etiology of cardiovascular disease, atherosclerosis takes a huge economic and social burden. Recent studies have shown that M2 macrophages play pivotal roles in the regression of atherosclerosis, including releasing multiple anti-inflammatory factors, promoting efferocytosis, and boosting tissue repair. Here we discuss the origin and identification of M2 macrophages, the signal transduction in M2 polarization, and its relationship with atherosclerosis resolution.