基于秀丽隐杆线虫模型的中药及其有效成分抗阿尔茨海默病的药理研究进展

Research progress on anti-Alzheimer’s disease pharmacology of traditional Chinese medicine and its active components based on Caenorhabditis elegans model

近年来,运用秀丽隐杆线虫模型对治疗阿尔茨海默病(AD)药物进行的研究与日俱增,通过线虫的直观表型及其深入的作用机制来探讨中药抗AD活性,从而实现药物的初步筛选。在此基础上深入研究,发现中药复方六味地黄丸、提取部位银杏叶提取物及有效成分石杉碱甲等均取得较好的临床疗效,秀丽隐杆线虫模型对中药资源研发具有一定的优势。综述利用线虫模型筛选的中药复方、提取部位、有效成分及其抗AD的作用机制,为抗AD中药新药研发提供思路和参考。

In recent years,the advantages of Caenorhabditis elegans and transgenic models have been used to study drugs for the treatment of Alzheimer’s disease(AD).Through the intuitive phenotype and in-depth mechanism of Caenorhabditis elegans,the antiAD activity of traditional Chinese medicine was discussed to realize the preliminary screening of effective drugs,the traditional Chinese medicine compound Liuwei Dihuang Pill,the extract of Ginkgo biloba leaves and the effective component huperzine A have achieved effective clinical efficacy,and the model of Caenorhabditis elegans has certain advantages in the research and development of traditional Chinese medicine resources.This paper reviews the traditional Chinese medicine compounds,extracts,active ingredients and their anti-AD mechanisms screened by the Caenorhabditis elegans model,providing ideas and references for the research and development of new anti-AD traditional Chinese medicine drugs.