1990年和2019年中国前列腺癌疾病负担及危险因素研究

Study on disease burden and risk factors of prostate cancer in China in 1990 and 2019

目的:分析1990年和2019年中国前列腺癌发病、死亡和疾病负担情况。方法:利用2019年全球疾病负担数据库,分析中国男性不同年龄组间1990年和2019年前列腺癌发病、死亡、伤残调整寿命年(DALY)、过早死亡损失寿命年(YLL)和伤残损失寿命年(YLD)。并对前列腺癌进行吸烟归因分析。结果:2019年中国前列腺癌发病人数为15.34万,发病率为21.17/10万,较1990年分别增长了481.06%和388.91%。2019年死亡人数5.44万,死亡率为7.50/10万,较1990年分别上升了167.98%和124.55%。2019年中国前列腺癌DALY、YLL和YLD分别为100.26万人年、90.37万人年和9.89万人年,较1990年分别上升了148.72%、132.13%和618.67%。2019年前列腺癌发病率、死亡率和DALY率均随年龄增长而升高,发病率、死亡率和DALY率最高的年龄组均为≥70岁组,分别为179.77/10万、85.16/10万和1259.53/10万。前列腺癌归因于吸烟导致的死亡人数、DALY和YLL分别为5016人、98276人年和88358人年。结论:我国前列腺癌的疾病负担在1990—2019年间有较大增长,对高风险人群进行定期筛查和戒烟是降低前列腺癌死亡率的有效应对措施,可以减轻前列腺癌的疾病负担。

Objective:To analyze the incidence,mortality and disease burden of prostate cancer in China in 1990 and 2019.Methods:The incidence,mortality,disability adjusted life year(DALY),premature death loss year(YLL)and disability life year(YLD)of prostate cancer in China in 1990 and 2019 were analyzed by using the 2019 Global Disease Burden database.Smoking attribution of prostate cancer was analyzed.Results:The number of prostate cancer in China was 153400 in 2019,with an incidence of 21.17/100000,representing an increase of 481.06%and 388.91%respectively compared with 1990.The number of deaths in 2019 was 54[KG0.5 mm]400,and the mortality was 7.50/100000,an increase of 167.98%and 124.55%respectively compared with 1990.In 2019,China’s prostate cancer DALY,YLL and YLD were 1002600,903700 person years and 98900 person years respectively.Compared with 1990,it increased by 148.72%,132.13%and 618.67%respectively.In 2019,the incidence,mortality and DALY rate of prostate cancer increased,and the incidence,mortality and DALY rate was the highest in the age group of over 70 years old,which was 179.77/100000 and 85.16/100000 and 1259.53/100000,respectively.The number of deaths due to smoking,DALY and YLL of prostate cancer were 5016,98276 and 88358,respectively.Conclusion:The disease burden of prostate cancer increased significantly in China from 1990 to 2019.Regular screening of high-risk groups and smoking cessation are effective measures to reduce the mortality of prostate cancer and reduce the disease burden of prostate cancer.