HPV阳性口咽癌的诊疗新进展

New progress in diagnosis and treatment of HPV-positive oropharyngeal carcinoma

近年来,口咽癌(OPC)的发病率不断增加,人乳头状瘤病毒(HPV)阳性OPC患者的预后更好已在多项研究中得到证实。HPV相关OPC有多种检测方法,包括P16免疫组织化学、聚合酶链式反应法或原位杂交法(in situ hybridization,ISH)检测HPV DNA、HPV RNA,逆转录酶聚合酶链式反应法检测HPV RNA。HPV阳性OPC患者良好的预后导致大量降级治疗试验的出现,传统的P16检测确诊的HPV阳性OPC患者存在一定的局限性,需要结合其他检测方法准确地筛选,更好地适用于降级治疗。本文对HPV相关OPC的发病趋势、检测方法及降级治疗试验的新进展进行综述。

In recent years,the incidence of oropharyngeal carcinoma(OPC)is increasing,while the better prognosis of patients with Human papillomavirus(HPV)positive oropharyngeal carcinoma has been confirmed in a number of studies.There are a variety of detection methods for HPV-associated oropharyngeal carcinoma.Including P16 immunohistochemistry,Polymerase Chain Reaction(PCR)or In situ hybridization(ISH)detection of HPV DNA,HPV RNA,Revers transcriptase Polymerase Chain Reaction(RT PCR)was used to detect HPV RNA.The better prognosis of patients with HPV-positive oropharyngeal carcinoma has led to the emergence of a large number of degraded treatment trials.The traditional P16 test has certain limitations in the diagnosis of patients with HPV-positive oropharyngeal carcinoma.It is necessary to combine with other detection methods to accurately screen out patients with HPV-positive oropharyngeal carcinoma and better apply to degraded therapy.In this article,we will briefly introduce the trend of HPV-associated oropharyngeal carcinoma,the detection methods and the new progress of degraded treatment trials.