线粒体功能障碍与多囊卵巢综合征相关性的研究进展

Research progress on the relationship between mitochondrial dysfunction and polycystic ovary syndrome

多囊卵巢综合征(PCOS)是以生殖、内分泌和代谢异常为特征的常见疾病,其发病机制不明确。线粒体在能量代谢等多种生命活动中发挥关键作用,线粒体相关调控机制受损可导致其功能障碍,常见有线粒体基因组异常、能量代谢异常、氧化应激、钙稳态失衡、生物合成减少、细胞增殖凋亡失衡、线粒体动力学紊乱及自噬异常等。PCOS作为多种疾病的相关因素被广泛认可,线粒体基因调控和功能紊乱与PCOS的发生发展密切相关,基于线粒体功能修复的治疗方法是PCOS治疗的新方向。该文就线粒体功能障碍与PCOS相关性的研究进展进行综述。

Polycystic ovary syndrome(PCOS) is a common disease characterized by reproductive,endocrine and metabolic abnormalities,and its pathogenesis is still unclear.Mitochondria play a key role in a variety of life activities such as energy metabolism.The impairment of mitochondrial related regulatory mechanisms can lead to its dysfunction,such as mitochondrial genome abnormalities,energy metabolism abnormalities,oxidative stress,calcium homeostasis imbalance,reduced biosynthesis,cell proliferation and apoptosis imbalance,mitochondrial dynamics disorder and autophagy abnormality.Mitochondrial dysfunction is widely recognized as a related factor of many diseases.Studies have confirmed that mitochondrial gene regulation and dysfunction are closely related to the occurrence and development of PCOS.The treatment method based on mitochondrial function repair is a new direction of PC OS treatment.This paper reviews the research progress of mitochondrial dysfunction and PCOS.