circRNA作用于急性缺血性脑卒中的研究进展

Research advance on circRNA in acute ischemic stroke

环状RNA(circRNA)介导内源性竞争RNA(ceRNA)调控网络已经被证实在急性缺血性脑卒中(AIS)损伤后的病理和生理过程中发挥关键作用,且分子诊断工具广泛应用后发现circRNA有望成为AIS的生物标志物,对上述研究进行归纳,可拓宽对AIS发生发展机制的研究视野,为其诊断和治疗提供新思路。

In recent years,circularRNA(circRNA) mediated endogenous competitive RNA(ceRNA) regulatory network has been proved to play a key role in pathological and physiological processes following acute ischemic stroke(AIS) injury.Moreover,circRNA is expected to be a biomarker of AIS after the wide application of molecular diagnostic tools.The summary of the above studies can broaden the vision of the pathogenesis of AIS and provide new ideas for its diagnosis and treatment.