生物正交反应与点击化学研究综述

Research review on bioorthogonal chemistry and click chemistry

2022年诺贝尔化学奖授予了生物正交反应和点击化学的开拓者。生物正交化学反应的发展,为生命体内化学反应的研究带来了革命性的突破,其中最灿烂夺目的要属点击化学,以分子功能为导向模块化的快速搭建,高效稳定地实现功能分子之间的链接。生物正交化学经历了一系列发展历程,反应实用场景由试剂瓶走向复杂的生物机体,并在化学生物学、药物研发、临床诊疗等多个领域展示出广阔的应用前景。生物正交反应和点击化学秉持“大道至简”——用简单高效的方法实现分子的复合功能,带领化学进入功能主义时代。

The 2022 Nobel Prize in Chemistry was awarded to the pioneers of the bioorthogonal chemistry and click chemistry.The development of bioorthogonal chemistry has achieved revolutionary breakthroughs to study the chemical reactions in vivo.The most dazzling reaction in bioorthogonal chemistry is click reaction,which is guided by function in molecular level,and links various functional molecules efficiently and stably through modular and simple construction.Bioorthogonal chemistry has gone through a series of development processes,whose reaction practical circumstances has changed from bottle to complex biological organism,which has shown broad application prospects in diversified fields such as chemical biology,drug discovery,clinical diagnosis.Bioorthogonal chemistry and click chemistry keep"the greatest truths are the simplest",which means realizing the functions of molecules with the most simple and efficient methods,leading chemistry into the era of functionalism.