低剂量阿司匹林联合尿激酶治疗对高危孕产妇围产期静脉血栓的影响

Effect of Low Dose Aspirin Combined with Urokinase on Perinatal Venous Thrombosis in High-risk Pregnant Women

目的:研究探讨低剂量阿司匹林联合尿激酶治疗对高危孕产妇围产期静脉血栓的影响。方法:回顾性选取我院2019年3月—2022年4月收治的高危产妇120例,采用数字随机数表法分为对照组与观察组,每组60例。对照组使用尿激酶治疗,观察组使用低剂量阿司匹林联合尿激酶治疗,对比两组产妇围产期静脉血栓发生率、凝血功能临床指标、不良反应发生率。结果:观察组围产期静脉血栓并发症总发生率低于对照组(P<0.05);观察组PT、APTT、PLT、FIB、PV指标治疗后均优于对照组(P<0.05);观察组不良反应发生率低于对照组(P<0.05)。结论:低剂量阿司匹林联合尿激酶治疗能有效减少高危孕产妇围产期静脉血栓并发症形成,大幅改善孕产妇的凝血功能,且用药安全性较高,对高危产妇围产期静脉血栓的治疗具有积极的临床意义。

Objective:To investigate the effect of low-dose aspirin combined with urokinase on high-risk pregnant women with perinatal venous thrombosis.Methods:A total of 120 high-risk puerperae admitted to our hospital from March 2019 to April 2022 were retrospectively selected and divided into control group and observation group by random number table method,with 60 cases in each group.The control group was treated with urokinase,while the observation group was treated with low-dose aspirin combined with urokinase.The incidence of perinatal venous thrombosis,clinical indicators of coagulation function and incidence of adverse reactions were compared between the two groups.Results:The total incidence of perinatal venous thrombosis in the observation group was lower than that in the control group(P<0.05).After treatment,PT,APTT,PLT,FIB and PV in the observation group were better than those in the control group(P<0.05).The incidence of adverse reactions in the observation group was lower than that in the control group(P<0.05).Conclusion:Low-dose aspirin combined with urokinase therapy can effectively reduce the complications of perinatal venous thrombosis in high-risk pregnant women,significantly improve the coagulation function of pregnant women,and has high safety,which has positive clinical significance for the treatment of perinatal venous thrombosis in high-risk pregnant women.