盐酸多奈哌齐治疗急性脑梗死后认知障碍患者的效果分析

Analysis of Effect of Donepezil Hydrochloride on Patients with Cognitive Impairment after Acute Cerebral Infarction

目的:探讨盐酸多奈哌齐对急性脑梗死后认知障碍患者认知功能及炎症反应的影响。方法:将120例急性脑梗死后认知障碍患者按照随机数字表法分为两组。对照组60例患者接受常规治疗措施,研究组60例患者在常规治疗的基础上采用盐酸多奈哌齐治疗。观察两组临床疗效,比较治疗前后认知功能改变,检测比较两组血清炎症因子水平治疗前后的变化。结果:研究组总有效率比对照组高(93.33%VS 78.33%,P<0.05)。治疗后两组患者的MoCA评分、MMSE评分均高于治疗前(P<0.05);研究组治疗后MoCA评分、MMSE评分高于对照组(P<0.05)。治疗后两组血清hs-CRP、IL-6、TNF-α水平均低于治疗前(P<0.05);研究组血清炎症因子水平治疗后低于对照组(P<0.05)。结论:盐酸多奈哌齐可以明显改善急性脑梗死后认知障碍患者的认知功能,降低患者机体炎症反应,临床疗效确切,值得临床推广。

Objective:To investigate the effect of donepezil hydrochloride on cognitive function and inflammatory reaction in patients with cognitive impairment after acute cerebral infarction.Method:120 patients with cognitive impairment after acute cerebral infarction were randomly divided into two groups.60 patients in the control group received routine treatment,while 60 patients in the study group received donepezil hydrochloride on the basis of routine treatment.To observe the clinical efficacy of the two groups,compare the changes of cognitive function before and after treatment,and detect and compare the changes of serum inflammatory factor levels in the two groups before and after treatment.Result:The total effective rate of the study group was higher than that of the control group(93.33%VS 78.33%,P<0.05).The MoCA score and MMSE score of the two groups after treatment were higher than those before treatment(P<0.05);MoCA score and MMSE score in the study group were higher than those in the control group after treatment(P<0.05).Serum hs CRP、IL-6、TNF in the two groups after treatment-αThe levels were lower than those before treatment(P<0.05);The level of serum inflammatory factors in the study group was lower than that in the control group after treatment(P<0.05).Conclusion:Donepezil hydrochloride can significantly improve the cognitive function of patients with cognitive impairment after acute cerebral infarction,reduce the inflammatory reaction of patients.It has a definite clinical effect and is worthy of clinical promotion.