脑小血管病的神经血管单元受损机制

Damage mechanism of neurovascular unit in cerebral small vessel disease

脑小血管病是一种临床常见的缓慢进展性脑血管病, 其病理机制涉及血管内皮功能障碍、血脑屏障破坏、神经元凋亡、神经胶质细胞激活以及炎症反应等。神经血管单元是脑结构和功能的基本单位, 其病理学改变与多种脑血管病密切相关。目前, 脑小血管病的神经血管单元损伤机制日益受到关注。文章对脑小血管病的神经血管单元受损机制进行了综述。

Cerebral small vessel disease(CSVD)is a common and slowly progressive cerebrovascular disease.Its pathological mechanism involves vascular endothelial dysfunction,blood-brain barrier destruction,neuronal apoptosis,glial cell activation,and inflammatory reaction.Neurovascular unit is the basic unit of brain structure and function,and its pathological changes are closely associated with many cerebrovascular diseases.At present,the damage mechanism of neurovascular unit in CSVD has been paid more and more attention.This article reviews the damage mechanism of neurovascular unit in CSVD.