老年稳定性冠心病患者血清CXCL12和TNF-α水平与冠状动脉病变程度的相关性

Correlation of serum levels of CXCL12 and TNF-αwith severity of coronary lesions in elderly patients with stable coronary heart disease

目的探讨老年稳定性冠心病患者血清CXC趋化因子配体12(CXCL12)和TNF-α水平与冠状动脉(冠脉)病变程度的相关性。方法将117例老年稳定性冠心病患者(冠心病组)分为单支病变组(46例)、两支病变组(39例)和多支病变组(32例),另以80例健康老年人作为对照组。检测各组患者血清CXCL12和TNF-α水平。分析冠心病组冠脉Gensini评分与血清CXCL12和TNF-α水平的相关性。结果冠心病组血清CXCL12和TNF-α水平高于对照组(P<0.05)。多支病变组和两支病变组血清CXCL12水平高于单支病变组,且多支病变组高于两支病变组(P<0.05),但三组间血清TNF-α水平均无统计学差异(P>0.05)。冠心病组患者血清CXCL12水平与冠脉Gensini评分呈正相关(r=0.749,P<0.01)。结论老年稳定性冠心病患者血清CXCL12和TNF-α水平升高。血清CXCL12水平与冠脉病变程度呈正相关。

Objective To analyze the correlation of serum levels of chemokine C-X-C motif ligand 12(CXCL12)and TNF-αwith the severity of coronary lesions in elderly patients with stable coronary heart disease(CHD).Methods A total of 117 elderly patients with stable CHD(group A)were divided into three groups of A1(with single vessel lesion,46 cases),A2(with two vessel lesions,39 cases)and A3(with multiple vessel lesions,32 cases).Another 80 healthy old people were taken as the controls(group C).Serum levels of CXCL12 and TNF-αwere detected in each group.The correlation of coronary Gensini score with serum levels of CXCL12 and TNF-αin group A was analyzed.Results Serum levels of CXCL12 and TNF-αin group A were higher than those in group C(P<0.05).Serum CXCL12 level in groups of A3 and A2 was higher than that in group A1,which in group A3 was higher than that in group A2(P<0.05).There was no significant difference in serum TNF-αlevel among groups of A1,A2 and A3(P>0.05).Serum level of CXCL12 was positively correlated with Genisin score(r=0.749,P<0.01).Conclusion Serum levels of CXCL12 and TNF-αare increased in elderly patients with stable CHD.Serum CXCL12 level is positively correlated with the severity of coronary lesions.