基于静息态功能磁共振成像分析帕金森患者静息态全脑功能连接及辅助诊断

Analysis of Resting-state Functional Connectivity and Auxiliary Diagnosis in Parkinson's Patients Based on Resting-state Functional Magnetic Resonance Imaging

目的:基于静息态功能磁共振成像(resting-state functional magnetic resonance,rs-fMRI)分析帕金森病(Parkinson’s Disease,PD)患者静息态全脑功能连接及其辅助诊断价值。方法:回顾性收集2022年1月至2022年7月本院收治的42例PD患者与42例对照组的临床及rs-fMRI资料。基于Matlab 2014b和DPARSFA软件对rs-fMRI的图像和数据进行预处理并计算脑功能连接密度(functional connectivity density,FCD)值。比较两组全脑FCD值的差异,并提取异常脑区。用受试者工作特征(ROC)曲线分析各FCD值差异脑区辅助诊断PD的效能,并计算曲线下面积(AUC)。以P<0.05为差异有统计学意义。结果:PD患者与对照组比较,FCD值显著降低的区域主要为右侧脑岛和右侧豆状核,PD患者FCD值显著升高的脑区主要分布于左侧颞下回和左侧海马旁回;左侧颞下回FCD值具有最好的诊断效能,ROC曲线下面积最高为0.8305,约登指数为0.595。结论:PD患者FCD差异脑区主要分布于左侧颞下回、左侧海马旁回、右侧脑岛以及右侧豆状核。同时,各差异脑区FCD值均对PD具有一定的辅助诊断价值,其中左侧颞下回FCD值的诊断效能最高。

Objective:To analyze the resting-state functional connectivity of the whole brain in Parkinson’s patients and its auxiliary diagnostic value based on resting-state functional magnetic resonance imaging(rs-fMRI).Methods:The clinical and rs-fMRI data of 42 PD patients and 42 controls admitted to our hospital from January 2022 to July 2022 were retrospectively collected.Based on Matlab 2014B and DPARSFA software,the images and data of rs-fMRI were preprocessed and FCD values were calculated.Differences in whole brain FCD values between the two groups were compared,and abnormal brain regions were extracted.The receiver operating characteristic(ROC)curve was used to analyze the efficacy of brain regions with different FCD values in assisting the diagnosis of PD,and the area under the curve(AUC)was calculated.P<0.05 was considered statistically significant.Results:Compared with the control group,the areas with significantly decreased FCD values were mainly in the right insula and right lentiform nucleus in PD patients,and the brain areas with significantly increased FCD values were mainly distributed in the left inferior temporal gyrus and left parahippocampal gyrus in PD patients.The FCD value of the left inferior temporal gyrus had the best diagnostic performance,with the highest area under the ROC curve of 0.8305 and a Youden index of 0.595.Conclusion:The FCD differential brain regions in PD patients were mainly distributed in the left inferior temporal gyrus,left parahippocampal gyrus,right insula and right lentiform nucleus.At the same time,the FCD values of different brain regions have certain auxiliary diagnostic value for PD,and the FCD values of the left inferior temporal gyrus have the highest diagnostic efficiency.