口腔扁平苔藓的治疗进展

The treatment progress of the oral lichen planus

口腔扁平苔藓(OLP)是一种病因复杂的口腔黏膜慢性炎症性疾病,属于口腔潜在恶性疾患(OPMD)范畴。药物治疗是目前OLP的主要治疗手段,尽管多种新型免疫抑制剂被广泛应用于OLP的治疗,但仍存在部分病例顽固难治、易复发,少数病例迁延恶变等现象。探索新的治疗药物及治疗手段,是解决当前困境的关键。随着现代生物技术及医学设备的发展,生物制剂、光动力疗法及光生物调节疗法等新兴治疗方式逐渐被应用于OLP的临床治疗。本文通过回顾文献,就近年OLP的治疗进展做一简要概述。

Oral lichen planus(OLP)is a chronic inflammatory disease of oral mucosa with complex etiology,which belongs to the category of oral potential malignant disorders.At present,drug therapy is the main treatment of OLP.Although a variety of new immunosuppressive agents are widely used in OLP treatment,some cases are still difficult to treat and easy to relapse,and a few cases end up with malignant transformation.Exploring new therapeutic drugs and methods is the key to solve the current dilemma.With the development of modern biotechnology and medical equipment,the biological agents,photodynamic therapy and photobiomodulation therapy are gradually applied to the clinical treatment of OLP.This article reviews the recent literature and provides a brief overview of the treatment progress of OLP.