Er:YAG激光联合他克莫司软膏治疗口腔扁平苔藓的临床研究

Clinical study of Er:YAG laser combined with tacrolimus ointment in the treatment of oral lichen planus

目的探讨Er:YAG激光联合0.1%他克莫司软膏治疗口腔扁平苔藓(OLP)的疗效。方法选取2020年12月至2021年9月于中山市人民医院口腔分院口腔黏膜病科就诊的OLP患者34例,采用随机数字表法将其分为两组,观察组采用Er:YAG激光联合0.1%他克莫司软膏治疗(n=17)、对照组单独使用0.1%他克莫司软膏治疗(n=17),使用χ2检验或Fisher确切概率法统计两种治疗方法的有效率并记录不良反应。结果Er:YAG激光联合0.1%他克莫司软膏治疗组总有效率达到100%,单独使用0.1%他克莫司软膏治疗组总有效率为64.7%,Fisher确切概率法统计结果显示,两种治疗方法差异具有统计学意义(P=0.018)。除个别患者在最初使用0.1%他克莫司软膏时有轻微刺痛、烧灼等不良反应,均可缓解并继续接受治疗。结论Er:YAG激光联合0.1%他克莫司软膏治疗OLP疗效显著。

Objective To explore the efficacy of Er:YAG laser combined with tacrolimus 0.1%ointment in the treatment of oral lichen planus.Methods A total of 34 oral lichen planus(OLP)patients who were treated in the Department of Oral Mucosa Diseases,Oral Branch,Zhongshan City People′s Hospital from December 2020 to September 2021 were selected and divided into two groups by random number table method.The two groups were randomly divided as follows,Er:YAG laser combined with tacrolimus 0.1%ointment treatment(17 cases in the observation group),and tacrolimus ointment treatment alone(17 cases in the control group).Theχ2 test or Fisher′s exact probability method was used to evaluate efficiency and record the number of adverse reactions of patients with the two treatment methods.Results The total effective rate in the observation group was 100%,while 64.7%in the control group.Fisher′s exact probability method showed that the significant difference between the two treatment methods(P=0.018).Except for a small part of patients who had mild stinging,burning and other adverse reactions when initially using tacrolimus 0.1%ointment,the pain from vast majority of patients could be relieved.Conclusion Er:YAG laser combined with tacrolimus 0.1%ointment has a significant effect in the treatment of OLP patients,which is faster than tacrolimus treatment alone in relieving pain,and has less adverse reactions.