树突状细胞在口腔扁平苔藓发病机制中的作用

The role of dendritic cells in the pathogenesis of oral lichen planus

树突状细胞(DC)是机体功能最强的专职抗原呈递细胞,它能高效地摄取、加工处理和呈递抗原,未成熟DC具有较强的迁移能力,成熟DC能有效激活初始T细胞,处于启动、调控和维持免疫应答的中心环节。口腔扁平苔藓(OLP)是一种常见的口腔黏膜慢性炎性疾病,固有层内大量T淋巴细胞呈密集带状浸润是其典型病理表现之一,表明OLP与T淋巴细胞介导的免疫反应有关。但关于免疫致病机制在OLP发病机制中的作用一直是未解的研究热点。为此,本综述旨概述DC在OLP发病机制中的作用。

Dendritic cells(DCs)are the most powerful professional antigen⁃presenting cells(APCs)in the body.They can efficiently absorb,process and present antigens.Immature DCs have strong migration ability.Mature DCs can effectively activate initial T cells and are in the central link of initiating,regulating and maintaining immune response.Oral lichen planus(OLP)is a common chronic inflammatory disease of oral mucosa.The dense band infiltration of a large number of T lymphocytes in lamina propria is one of its typical pathological manifestations,indicating that OLP is related to T lymphocyte mediated immune response.However,the role of immune pathogenesis in the pathogenesis of oral lichen planus has been an unsolved research hotspot.Therefore,this review aims to summarize the role of dendritic cells in the pathogenesis of OLP.