上海地区体检人群幽门螺杆菌定植水平与代谢综合征相关性分析

Correlation analysis of Helicobacter pylori colonization level and metabolic syndrome in physical examination population in Shanghai

目的分析基于性别分组的幽门螺杆菌(Hp)胃内定植水平与代谢综合征(MS)的相关性,为降低MS患病率提供流行病学依据。方法收集2019年10月—2020年9月复旦大学附属华东医院30376名体检者临床资料。将30376名体检者分为MS组(3300例)和非MS组(27076名)。探讨发生MS的危险因素,分析Hp胃内定植水平等因素与罹患MS的相关性。结果30376名体检者Hp总阳性率为24.1%,男性阳性率为26.3%,女性阳性率为21.6%,不同性别Hp阳性率差异有统计学意义(P<0.001);MS总患病率为10.9%,男性患病率为15.6%,女性患病率为5.7%,不同性别患病率差异有统计学意义(P<0.001)。不同MS评分组男性Hp阳性率均高于女性(P<0.05);不同Hp定植水平组男性MS的患病率均高于女性(P<0.05)。高Hp定植水平是男性罹患MS的危险因素。结论上海地区体检人群中,男性高Hp定植水平与MS有一定的相关性,建议Hp阳性的男性及时进行Hp根除治疗,以降低MS的发生风险。

Objective To analyze the relationship between the level of Helicobacter pylori(Hp)colonization in the stomach and the metabolic syndrome(MS)based on female and male grouping,and to provide an epidemiological basis for clinically reducing the prevalence of MS.Methods The clinical data of 30376 subjects in Huadong Hospital of Fudan University from October 2019 to September 2020 were collected and analyzed retrospectively,and the subjects were classified into MS group(3300 cases)and non-MS group(27076 cases).The risk factors of MS were analyzed,and the correlation of the level of Hp colonization in the stomach with MS was evaluated.Results The prevalence of Hp was 24.1%,26.3%for males and 21.6%for females,and there was statistical significance between females and males(P<0.001).The prevalence of MS was 10.9%,15.6%for males and 5.7%for females,and there was statistical significance between females and males(P<0.001).In the different groups of MS scores,the prevalence of Hp in males was higher than that in females(P<0.05).In the different groups of colonization values,the prevalence of MS in males was higher than that in females(P<0.05).High colonization level of Hp was risk factor of MS in males.Conclusions In Shanghai physical examination population,there is a correlation between high colonization level of Hp and MS in males.It is recommended that males with Hp-positive and MS should receive Hp eradication treatment in time.