重症急性胰腺炎肠黏膜屏障功能障碍的研究进展

Research progress of intestinal mucosal barrier dysfunction in severe acute pancreatitis

重症急性胰腺炎(SAP)是临床上最常见的急腹症之一,病死率高,可伴有多脏器损伤,肠道是最晚修复的损伤器官。肠道不仅可以吸收营养物质,也可以抵御外来有害物质,肠黏膜屏障可阻断肠腔和人体内部组织,有效防止肠道外来有害物质进入血液循环,维持正常的肠道功能,降低肠源性感染的可能性。SAP可引起肠道缺血和缺氧,机体炎症反应也可破坏肠黏膜屏障,引起肠道细菌移位并损伤肠道功能,加速SAP的进展。本文检索大量SAP相关文献进行分析归纳,总结了SAP肠黏膜屏障功能损伤的机制,以期为SAP肠道损伤患者的临床诊疗提供参考和指导。

Severe acute pancreatitis(SAP)is one of the most common acute abdomen diseases in clinic,and it has a high mortality and can be accompanied by organ damage.The intestinal damage is the slowest to repair.The intestinal mucosal barrier(IB)blocks the intestinal cavity and the internal tissues of the body.The intestinal tract can not only absorb nutrients but also resist foreign harmful substances,effectively prevent foreign harmful substances in the intestinal tract from entering blood circulation,maintain normal intestinal function,and reduce the possibility of enterogenous infection.SAP can cause intestinal ischemia and hypoxia.The inflammatory response of the body can also directly damage the intestinal mucosal barrier,causing intestinal bacterial translocation.It can damage the intestinal function and accelerate the progress of SAP.In this paper,a large number of relevant literature were retrieved for analysis and summary,in order to help know the mechanism of intestinal mucosal barrier dysfunction of SAP and the part of intestinal mucosal barrier in the progression of SAP,and to guide the treatment of complications of SAP.