摘要
生物相容水/水微囊在药物递送、医学治疗等领域具有重要应用.本文通过设计同轴微流控器件,结合数值模拟优化和流动阻力分析,实现一步法高通量可控制备大小均匀、尺寸可控、壁厚可调、生物相容的水/水微囊.采用实验研究和数值模拟相结合的方式,研究了微流控器件结构、内相流速、外相流速、外相/空气界面张力、内相/外相界面张力、内相黏度和外相黏度等参数对水/水微囊直径和壁厚的调控规律.通过微通道流动阻力分析,设计多通道平行放大微流控器件,实现尺寸均匀可控水/水微囊的高通量制备.验证了生物相容水/水微囊作为活性物质的理想载体,可以通过改变pH或溶解囊壁释放载体,进而实现活性物质的pH响应释放,为其实际应用奠定了基础.
Biocompatible water/water microcapsules are of great significance for drug delivery and medical therapy.In this paper,co-axial microfluidic devices were designed via the optimization by numerical simulations and the analysis of flow resistance to realize one-step high-throughput controlled preparation of water/water microcapsules with good uniformity,tunable size and shell thickness,and excellent biocompatibility.Specifically,the influences of device design,inner phase flow rate,outer phase flow rate,outer phase/air interfacial tension,inner phase/outer phase interfacial tension,inner phase viscosity and outer phase viscosity on the diameter and shell thickness of water/water microcapsules were systematically investigated by means of experiments and simulations.By carefully analyzing the flow resistance of microchannels,microfluidic devices were parallelly amplified to achieve high-throughput prepa⁃ration of water/water microcapsules with controlled size.Biocompatible water/water microcapsules are ideal delivery vehicles for various actives,showing controlled pH-triggered release of encapsulated cargos,which pave the way for their practical applications.
作者
翟小威
潘湄蝶
石盼
赵鹏
陈东
ZHAI Xiaowei;PAN Meidie;SHI Pan;ZHAO Peng;CHEN Dong(Zhejiang Key Laboratory of Smart Biomaterials,College of Chemical and Biological Engineering,Zhejiang University,Hangzhou 310027,China;College of Energy Engineering,State Key Laboratory of Clean Energy Utilization,Zhejiang University,Hangzhou 310003,China;Department of Medical Oncology,the First Affiliated Hospital,School of Medicine,Zhejiang University,Hangzhou 310003,China)
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
2022年第12期92-101,共10页
Chemical Journal of Chinese Universities
基金
国家重点研发计划项目(批准号:YS2021YFC30000089)
浙江省自然科学基金(批准号:Y20B060027)
国家自然科学基金(批准号:21878258)资助。
关键词
微流控
微通道
微囊
可控释放
平行放大
Microfluidics
Microchannel
Microcapsule
Controlled release
Parallel amplification