一步法高通量可控制备生物相容水/水微囊及其响应释放

One-step High-throughput Controlled Preparation of Biocompatible Water/Water Microcapsules with Triggered Release

生物相容水/水微囊在药物递送、医学治疗等领域具有重要应用.本文通过设计同轴微流控器件,结合数值模拟优化和流动阻力分析,实现一步法高通量可控制备大小均匀、尺寸可控、壁厚可调、生物相容的水/水微囊.采用实验研究和数值模拟相结合的方式,研究了微流控器件结构、内相流速、外相流速、外相/空气界面张力、内相/外相界面张力、内相黏度和外相黏度等参数对水/水微囊直径和壁厚的调控规律.通过微通道流动阻力分析,设计多通道平行放大微流控器件,实现尺寸均匀可控水/水微囊的高通量制备.验证了生物相容水/水微囊作为活性物质的理想载体,可以通过改变pH或溶解囊壁释放载体,进而实现活性物质的pH响应释放,为其实际应用奠定了基础.

Biocompatible water/water microcapsules are of great significance for drug delivery and medical therapy.In this paper,co-axial microfluidic devices were designed via the optimization by numerical simulations and the analysis of flow resistance to realize one-step high-throughput controlled preparation of water/water microcapsules with good uniformity,tunable size and shell thickness,and excellent biocompatibility.Specifically,the influences of device design,inner phase flow rate,outer phase flow rate,outer phase/air interfacial tension,inner phase/outer phase interfacial tension,inner phase viscosity and outer phase viscosity on the diameter and shell thickness of water/water microcapsules were systematically investigated by means of experiments and simulations.By carefully analyzing the flow resistance of microchannels,microfluidic devices were parallelly amplified to achieve high-throughput prepa⁃ration of water/water microcapsules with controlled size.Biocompatible water/water microcapsules are ideal delivery vehicles for various actives,showing controlled pH-triggered release of encapsulated cargos,which pave the way for their practical applications.