蒙脱石负载氧化铈纳米酶用于克罗恩肠炎治疗

CeO_(2)@montmorillonite Nanozyme for Crohn’s Disease Therapy

通过水热法合成由临床用药蒙脱石(Montmorillonite,MMT)负载的高效纳米酶氧化铈(Cerium dioxide,CeO_(2)),通过开展体内外实验,拓展其在炎症性肠病治疗中的普适性.结果显示,CeO_(2)@MMT具有良好的类超氧化物歧化酶活性及类过氧化氢酶活性,并且在小鼠克罗恩病的治疗中体现了明显的疗效及优异的生物安全性,为CeO_(2)@MMT的应用拓宽了方向.

Inflammatory bowel disease(IBD)is a chronic,nonspecific disease that is refractory and therefore affects the normal life of patients to a great extent.Although the global incidence of this disease is increasing year by year,ideal therapeutic drugs are still lacking in clinical practice.Inspired by the antioxidant activity of natural enzymes in organisms,the therapeutic strategies of natural enzymes for inflammatory diseases have come into view.However,natural enzymes have the limitations of poor stability and high cost.Here,we loaded cerium oxide on a montmorillonite surface to obtain CeO_(2)@montmorillonite(CeO_(2)@MMT)nanozyme and verified that it has an excellent curative effect and universality in the treatment of Crohn’s disease(CD)through in vitro and in vivo experiments.CeO_(2)@MMT showed good superoxide dismutase-and catalase-like activity in vitro.Its negative charges enable it to target the positively charged intestinal inflammatory site and exert an anti-inflammatory effect at the focus.Thus,it showed obvious curative effects and excellent biosafety in the treatment of CD in mice,which broadened the spectrum of the application of nanozymes.