摘要
随着正电子发射断层扫描(PET)技术的进步,高效^(18)F标记反应显现出重大的研究价值.同时,在有机氟化学的快速发展下,研究人员已开发出一系列产生二氟甲基自由基(·CHF_(2))的一碳合成子,得以被引入到^(18)F标记反应中.本文从化学原理出发,总结了近年来·CHF_(2)合成子、碳氢键活化反应及^(18)F标记的研究,并展望了未来的研究趋势.
With the progress of positron emission tomography(PET),the study of efficient ^(18)F-labeling reactions is of great value.Meanwhile,with the rapid development of organic fluorine chemistry,researchers have developed a series of reagents as C1 synthons to yield difluoromethyl radical(·CHF_(2)),which can be introduced into the ^(18)Flabeling reactions.In this review,we analyzed from the perspective of chemical principles and summarized the recent studies on·CHF_(2) synthons,C—H bond activation and related ^(18)F-labeling reactions.Furthermore,the research trends and hotspots were discussed.
作者
李嘉颢
梁炜秋
穆博帅
刘志博
LI Jiahao;LIANG Weiqiu;MU Boshuai;LIU Zhibo(College of Chemistry and Molecular Engineering,Peking University,Beijing 100871,China;Peking University-Tsinghua University Center for Life Science,Beijing 100871,China)
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
2022年第12期311-317,共7页
Chemical Journal of Chinese Universities
基金
国家自然科学基金(批准号:U1867209)。