二氟甲基自由基反应及其在^(18)F标记中的应用

Difluoromethyl Radical Reaction and Its Application in ^(18)F-Labeling

随着正电子发射断层扫描(PET)技术的进步,高效^(18)F标记反应显现出重大的研究价值.同时,在有机氟化学的快速发展下,研究人员已开发出一系列产生二氟甲基自由基(·CHF_(2))的一碳合成子,得以被引入到^(18)F标记反应中.本文从化学原理出发,总结了近年来·CHF_(2)合成子、碳氢键活化反应及^(18)F标记的研究,并展望了未来的研究趋势.

With the progress of positron emission tomography(PET),the study of efficient ^(18)F-labeling reactions is of great value.Meanwhile,with the rapid development of organic fluorine chemistry,researchers have developed a series of reagents as C1 synthons to yield difluoromethyl radical(·CHF_(2)),which can be introduced into the ^(18)Flabeling reactions.In this review,we analyzed from the perspective of chemical principles and summarized the recent studies on·CHF_(2) synthons,C—H bond activation and related ^(18)F-labeling reactions.Furthermore,the research trends and hotspots were discussed.