手性纳米材料:生物成像、生物传感与治疗

Chiral Nanomaterials:Bioimaging,Biosensing and Therapeutics

手性无机纳米结构不仅形貌和结构可调控、易于表面功能化修饰,而且光学性质独特,在生物领域的应用上展现了很大的优异性.本文综述了近年来手性纳米技术在生物医学领域的研究进展,重点介绍了手性金属和手性半导体纳米结构的合成策略、圆二色效应、光手性机制及在生物成像、生物传感、肿瘤以及神经退行性疾病等医学领域的应用.手性纳米材料的研究丰富了生物化学的纳米技术手段,促进了肿瘤等重大疾病诊断与治疗技术的进步,推动了手性在生命科学中的发展,鼓励了研究者对这一新兴领域的持续探索与挑战.

Chiral inorganic nanostructures not only display great flexibility in morphology and structure regulation and simplicity in surface functionalization,but also exhibit unique optical properties,showing great excellence in the application of biological field.This review comprehensively discusses the research progress of chiral nanotechnology in the biomedical field in recent years,focusing on the chiral metal-or semiconductor-based nanostructures in terms of the synthesis strategy,circular dichroism effect,mechanisms of optical chirality and their performances in biomedical applications such as bioimaging,biosensing,tumours and neurodegenerative diseases therapies.These researches of chiral nanomaterials enrich biochemical nanotechnology means,promote the progress of diagnosis and therapeutic techniques for major diseases such as cancer,give a boost to the chirality in life sciences,and encourage researchers to continue to explore and challenge this emerging field.