乳腺癌生存者经济毒性现状及其对生活质量的影响研究

Status of cancer-related financial toxicity among breast cancer survivors and its impact on their quality of life

目的描述乳腺癌生存者自我报告的经济毒性现状,并分析其对生活质量的影响。方法于2021年6-10月,采用方便抽样方法,应用一般资料调查表、慢性病治疗的经济毒性功能评估综合评分量表(COST-FACIT-v2)和癌症患者生命质量测定量表(FACT-G),对上海市徐汇区3家社区卫生服务中心和1个患者团体组织的乳腺癌生存者进行横断面调查。结果共收集312例有效问卷,自我报告的经济毒性平均得分为(22.70±8.39)分。乳腺癌生存者经济毒性与生活质量总分(r_(总)=0.283,P<0.001)和生理状况(r_(1)=0.219,P<0.001)、社会/家庭状况(r_(2)=0.124,P=0.029)、情感状况(r_(3)=0.251,P<0.001)以及功能状况(r_(4)=0.227,P<0.001)各维度呈正相关。分层回归分析结果显示,经济毒性可独立解释乳腺癌生存者生活质量变异的6.1%。结论我国乳腺癌生存者普遍存在不同程度的经济毒性。在控制人口学、疾病因素变量后,经济毒性是降低乳腺癌生存者生活质量的独立风险因素,应引起医护工作者的关注。

Objective To describe the status of cancer related financial toxicity status among breast cancer survivors and evaluate its influence on quality of life.Methods With the convenient sampling method,a cross-sectional survey was conducted on the breast cancer survivors by using the general information questionnaire,comprehensive score for financial toxicity-functional assessment of chronic illness therapy version 2(COST-FACIT-v2),and functional assessment of cancer therapy general(FACT-G)in 3 Community Health Centers and Cancer Survivors'Club in Xuhui district of Shanghai from June to October 2021.Results A total of 312 effective questionnaires were included,and the average score of COST-FACIT-v2 was(22.70±8.39)points.Financial toxicity of breast cancer survivors was positively correlated with total score of QOL(r_(total)=0.283,P<0.001),the physical condition(r_(1)=0.219,P<0.001),the social/family condition(r_(2)=0.124,P=0.029),emotional condition(r_(3)=0.251,P<0.001),and functional condition(r_(4)=0.227,P<0.001),respectively.The results of hierarchical regression showed that financial toxicity independently accounted for 6.1%of the variance in quality of life of breast cancer survivors.Conclusion There are generally varying degrees of financial toxicity in breast cancer survivors.Financial toxicity is an independent risk factor for decreasing quality of life of breast cancer survivors when controlling for demographic and clinical variables,to which attention should be paid.