MTHFR C677T基因多态性与中国汉族人群高血压患者左心室肥厚的相关性分析

Correlation analysis of MTHFR C677T gene polymorphism and left ventricular hypertrophy in Chinese Han population with hypertension

目的:探讨中国汉族人群高血压患者亚甲基四氢叶酸还原酶(MTHFR)C677T基因多态性与左心室肥厚(left ventricular hypertrophy,LVH)的关系。方法:收集2020年1月至2021年4月就诊的中国汉族人群高血压病患者342例,检测MTHFR C677T基因多态性,同时进行心脏超声检查。按照基因型分为野生纯合型(CC)、突变杂合型(CT)和突变纯合型(TT),通过单因素方差分析和多元线性回归分析,研究MTHFRC677T基因多态性与LVH指标之间的相关性。结果:CC基因型116例、CT基因型173例、TT基因型53例,3种基因型的LVH指标:室间隔厚度(F=3.891,P=0.021)、左心室质量(F=4.387,P=0.013)、左心室质量指数(F=3.339,P=0.037)差异有统计学意义。在校正了与多态性相关的潜在混杂因素后,仍发现MTHFR C677T基因多态性对LVH指标具有显著正向影响(P<0.05)。结论:MTHFR C677T的基因多态性与中国汉族人群高血压患者的LVH指标具有相关性,可能是中国汉族人群高血压患者发生LVH的遗传易感性标志物。

OBJECTIVE To investigate the relationship between the gene polymorphism of methylenetetrahydrofolate reductase(MTHFR)C677Tand left ventricular hypertrophy(LVH)in Chinese Han population with hypertension.METHODS A total of 342 patients with hypertension in the Chinese Han population who visited our hospital from January 2020 to April 2021 were collected,and the MTHFR C677T gene polymorphism was detected,and echocardiography was performed at the same time.According to genotype,it is divided into wild homozygous(CC),mutant heterozygous(CT)and mutant homozygous(TT).The correlation between the gene polymorphism of MTHFRC677Tand LVH indexes was analysed using a one-way analysis of variance(ANOVA),as well as multiple linear regression model.RESULTS There were 116 cases of CCgenotype,173 cases of CTgenotype,and 53 cases of TTgenotype in the study.The three genotypes of LVH indexes had significant differences in ventricular septal thickness(F=3.891,P=0.021),left ventricular mass(F=4.387,P=0.013),and left ventricular mass index(F=3.339,P=0.037).After adjusting for potential confounding factors related to polymorphism,we still found that MTHFR C677T gene polymorphism had a significant positive effect on LVH indexes(P<0.05).CONCLUSION The gene polymorphism of MTHFR C677T was associated with the LVH indexes in Chinese Han population patients with hypertension,which may be a genetic susceptibility marker for LVH in Chinese Han population hypertensive patients.