麝香保心丸口服联合替奈普酶溶栓对AMI患者心功能及血清细胞因子水平的影响

Effect of Shexiang Baoxin Pill Combined with Teneprase Thrombolysis on Cardiac Function and Serum Cytokine Level in Patients with AMI

目的:探究麝香保心丸(SBP)口服联合替奈普酶(TNK-tPA)溶栓治疗急性心肌梗死(AMI)患者的效果。方法:收集该院102例AMI患者(2020年1月—2021年1月),按治疗方案不同分成A组51例,B组51例。B组接受TNK-tPA溶栓治疗,A组接受SBP口服联合TNK-tPA溶栓治疗。对比2组总有效率、治疗前后左室舒张末期内径(LVEDD)、左室收缩末期内径(LVESD)、左室射血分数(LVEF)、血清一氧化氮(NO)、内皮素-1(ET-1)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、心肌酶谱指标[肌酸激酶同工酶(CK-MB)、乳酸脱氢酶(LDH)、肌酸激酶(CK)、羟丁酸脱氢酶(HBDH)]水平。结果:A组总有效率94.42%(48/51)较B组78.43%(40/51)高(P<0.05);治疗1个月A组LVEDD、LVESD较B组低,LVEF较B组高(P<0.05);治疗1个月A组血清IL-6、TNF-α水平较B组低(P<0.05);治疗1个月A组血清ET-1水平较B组低,血清NO水平较B组高(P<0.05);治疗1个月A组血清CK-MB、LDH、CK、HBDH水平较B组低(P<0.05)。结论:SBP口服联合TNK-tPA溶栓治疗AMI患者效果显著,可有效提高心功能,减轻机体炎性反应,改善血管内皮功能,减轻心肌损伤。

Objective:To investigate the effect of Shexiang Baoxin Pill (SBP)orally combined with tenecteplase (TNK-tPA)thrombolysis in the treatment of patients with acute myocardial infarction (AMI).Methods:A total of 102 patients with AMI in our hospital (January 2020-January 2021)were collected and divided into 51 cases in group A and 51 cases in group B according to different treatment plans.Group B received TNK-tPA thrombolytic therapy,and group A received SBP oral combined with TNK-tPA thrombolytic therapy.The total effective rate,left ventricular end-diastolic diameter (LVEDD),left ventricular end-systolic diameter (LVESD),left ventricular ejection fraction (LVEF),serum nitric oxide (NO),endothelin-1 (ET)before and after treatment were compared between the two groups.-1),interleukin-6 (IL-6),tumor necrosis factor-α (TNF-α),myocardial enzymes[creatine kinase isoenzyme (CK-MB),lactate dehydrogenase (LDH),creatine kinase (CK),hydroxybutyrate dehydrogenase (HBDH)]levels.Results:The total effective rate of group A was 94.42% (48/51)higher than that of group B (78.43% (40/51)(P<0.05);after 1 month of treatment,the LVEDD and LVESD of group A were lower than those of group B,and the LVEF was higher than that of group B (P<0.05);the levels of serum IL-6 and TNF-α in group A were lower than those in group B after one month of treatment (P<0.05);the level of serum ET-1 in group A was lower than that in group B after one month of treatment,and the level of serum NO Compared with group B,the serum levels of CK-MB,LDH,CK and HBDH in group A were lower than those in group B after 1 month of treatment (P<0.05).Conclusion:SBP orally combined with TNK-tPA thrombolysis in the treatment of AMI patients has a significant effect,which can effectively improve cardiac function,reduce the body’s inflammatory response,improve vascular endothelial function,and reduce myocardial injury.