从脂肪组织的内分泌功能角度探讨其在慢性阻塞性肺疾病中的作用机制研究

Role of Endocrine Function of Adipose Tissue in the Development of Chronic Obstructive Pulmonary Disease:a Review of Recent Advances

脂肪组织除了通过其力学特征或机械功能对周边组织器官产生影响以外,还可以凭借非物理性的内分泌功能通过脂肪因子输出信号方式有效地建立起与呼吸系统等远程器官的互作信息网络,进而参与多种肥胖相关疾病的发生与发展。作为内分泌领域的突破性进展之一,脂肪组织的内分泌功能受到生命科学领域的关注。近年来,多项流行病调查研究揭示了肥胖是造成慢性阻塞性肺疾病(COPD)等呼吸系统疾病肺功能损害重要的危险因素。基于此,本文将分别梳理脂联素、瘦素、内脂素等脂肪因子在COPD中的作用机制,从脂肪组织内分泌功能角度为COPD的防治研究提供新思路。

In addition to affecting adjacent tissues and organs through its mechanical characteristics or mechanical functions,adipose tissue participates in the development of a variety of obesity-related diseases by effectively establishing an interaction information network with organs of the respiratory system and other remote organs through signaling pathways of adipokines secreted by adipocytes.As a breakthrough in the field of endocrinology,the endocrine function of adipose tissue has attracted increasing attention in life sciences.A number of recent epidemiological studies have revealed that obesity is an important risk factor for chronic obstructive pulmonary disease and other respiratory impairments.We reviewed recent advances in the role of adiponectin,leptin,endolipin and other adipocytokines in the development of COPD,providing new ideas for the prevention and treatment of COPD from the perspective of endocrine function of adipose tissue.