利拉鲁肽改善2型糖尿病合并周围血管病变患者经皮氧分压的效果分析

Effect of Liraglutide on transcutaneous oxygen partial pressure in patients with type 2 diabetes mellitus peripheral vascular disease

目的探讨T2DM合并周围血管病变患者使用利拉鲁肽治疗对足背经皮氧分压(TcPO_(2))的影响。方法选取2017年6月至2020年6月于西安交通大学第二附属医院内分泌科治疗的T2DM合并周围血管病变患者99例,分为青年组(<40岁)34例,中年组(40~60岁)44例,老年组(>60岁)21例。在降压、降脂基础上加用利拉鲁肽至少24周,比较各组治疗前后足背TcPO_(2)变化。结果青年、中年组治疗后TcPO_(2)升高,青年组改善更明显(P<0.05)。老年组治疗前后TcPO_(2)无明显变化。结论利拉鲁肽可改善青中年T2DM合并周围血管病变患者下肢微血管灌注。

Objective To investigate the effect of Liraglutide on transcutaneous oxygen partial pressure(TcPO_(2))in dorsum of foot in patients with type 2 diabetes mellitus(T2DM)peripheral vascular disease.Methods We retrospectively analyzed the data of 99 patients with T2DM peripheral vascular disease in our department from June 2017 to June 2020.They were divided into young group(<40 years,n=34),middle-aged group(40~60 years,n=44)and elderly group(>60 years,n=21).Patients received antiplatelet therapies,antihypertensive treatmentand lipid-lowering treatment if necessary.Liraglutide was administrated at least for 24 weeks.The changes of TcPO_(2) in dorsum of foot were evaluated.Results After treatment,the levels of TcPO_(2) increased in both young and middle-aged groups,and the improvement was more obvious in the young group(P<0.05).There was no significant change in TcPO_(2) in the elderly group before and after Liraglutide treatment.Conclusion Liraglutide increased the micro vascular perfusion of lower limbs in young and middle-aged patients with T2DM peripheral vascular disease.