摘要
DM是以血糖水平升高为主要特征的代谢性疾病。持续高血糖给组织和器官带来损害的同时,也增加认知障碍发生风险。IL-1β、IL-6、TNF-α及C-RP等可参与机体免疫反应,调节认知功能,其表达异常可能影响大脑突触可塑性,加剧认知障碍。本文对DM认知障碍患者相关炎症因子改变及意义的研究进展进行综述。
Diabetes mellitus is a metabolic disease mainly characterized by elevated blood glucose levels.Persistent hyperglycemia not only cause damage to tissues and organs,but also increase the risk of cognitive impairment.IL-1β,IL-6,TNF-αand C-RP can participate in the body immune response and regulate the cognitive function.The abnormal expression of them may affect synaptic plasticity in the brain and exacerbate cognitive impairment.This review summarizes the research progress on the changes of related inflammatory factors in diabetic patients with cognitive impairment.
作者
廉硕硕
王锋
惠宗光
贺圣文
蒋与刚
LIAN Shuoshuo;WANG Feng;HUI Zongguang(School of Public Health,Weifang Medical University,Weifang 261053,China)
出处
《中国糖尿病杂志》
CAS
CSCD
北大核心
2022年第10期786-789,共4页
Chinese Journal of Diabetes
基金
国家自然科学基金(81903303)。
关键词
糖尿病
认知障碍
免疫反应
炎症因子
Diabetes mellitus
Cognitive impairment
Immune response
Inflammatory factors
