胰岛β细胞自噬及其影响因素

Autophagy of isletβcell and its influencing factors

DM是常见代谢性疾病,胰岛β细胞衰竭是主要发病机制。自噬是一种溶酶体依赖的降解过程,对维持胰岛β细胞稳态、结构和功能有重要意义。影响胰岛β细胞自噬常见影响因素有氧化应激、内质网应激、炎症及药物等。本文对胰岛β细胞自噬及其影响因素进行综述。

Diabetes mellitus is a common metabolic disease,and isletβcell failure is its main pathogenesis.Autophagy is a lysosomal-dependent degradation process,which is extremely important for maintaining isletβcell homeostasis,structure and function.There are many factors that affect isletβcell autophagy,including oxidative stress,endoplasmic reticulum stress,inflammation and drugs.This article reviews the research progress of isletβcells autophagy and its influencing factors.