“黄连-干姜”药对用于治疗溃疡性结肠炎研究进展

Research Progress of Coptis-Dried Ginger for the Treatment of Ulcerative Colitis

中医将溃疡性结肠炎归属于“痢疾”“肠澼”“泄泻”“下利”等病的范畴,历代医家常常运用寒热配伍法治疗胃肠病。其中,“黄连-干姜”是一组常用的寒热药对,二药配伍,寒热并用,可用于寒热互结、肠鸣下利等证。现代药理研究发现黄连、干姜均具有抗炎、抗氧化等与溃疡性结肠炎相关的药理活性,通过检索文献,对“黄连-干姜”药对在古方中应用及其有效成分与组分的现代研究进行总结,为其进一步研究提供参考依据。

Traditional Chinese medicine often assigns ulcerative colitis to diseases such as“dysentery”“intestinal diarrhea”“diarrhea”and“xiali”.Physicians of the past dynasties often used the combination of cold and heat to treat gastrointestinal diseases.Among them,Coptis-Dried Ginger is a group of commonly used cold and heat medicine pairs,the two medicines are compatible,cold and heat are used together,and can be used for the syndromes of cold and heat mutual congestion,intestinal ringing and lowering benefits.Modern pharmacological studies have found that Coptis and Dried Ginger have anti-inflammatory,antioxidant and other pharmacological activities related to ulcerative colitis.In this article,by searching the literature,the application of Coptis-Dried Ginger in ancient prescriptions and its effective ingredients and components modern research is summarized to provide reference basis for further research.