缺血性脑损伤中生物标志物的研究进展

Research advances of biomarkers related to ischemic brain injury

缺血性脑损伤是临床常见的脑血管疾病,导致脑组织缺血、缺氧,致使脑组织失去功能,是导致死亡和残疾的重要疾病之一。当前关于应用生物标志物来评估患者的病情及预后的研究逐渐展开,其发挥的作用逐渐受到重视。通过应用分子生物学可对缺血性脑损伤特定的生物标志物进行检测,从而做到疾病的早期诊断和及时干预,改善患者预后。文章对目前常用的生物标志物,如炎性生化反应标志物、神经系统血清标志物、非编码RNA、血清铁蛋白等的现阶段研究进展进行综述。

Ischemic brain injury is a common clinical cerebrovascular disease,which damages the brain tissue by deprivation of blood flow and oxygen,as a leading disease of mortality and disability.As the study of biomarkers in clinical practice,its role in ischemic brain injury is gradually appreciated.Applying molecular biology to detect specific biomarkers of ischemic brain injury to achieve early diagnosis and timely intervention of the disease has important implications for improving prognosis.Therefore,this paper reviews the present results of the biomarkers associated with ischemic brain injury,such as biochemical markers related to the inflammatory response,neurological serum markers,non‑coding ncRNA,and serum ferritin.