铁死亡在脑损伤中的研究进展

Research progress on ferroptosis in brain injury

铁死亡是近年来发现的一种新型细胞死亡机制,通常在细胞死亡过程中伴有大量铁积累和脂质过氧化作用。铁死亡在脑损伤中起关键作用,铁死亡抑制剂可有效改善铁稳态、脂质代谢、氧化还原稳定、神经元重塑和创伤后功能恢复。文章综述了铁死亡最新分子机制及其进展,重点综述其在脑缺血、脑出血、外伤性脑损伤和其他急性脑损伤中的作用。理解铁死亡的作用,可为进一步了解脑损伤发病机制及寻找新的治疗靶点提供参考。

Ferroptosis is a new type of cell death that was discovered in recent years and usually accompanied by a large amount of iron accumulation and lipid peroxidation during the cell death process.Ferroptosis plays a key role in brain injury.Ferroptosis inhibitors can effectively improve iron homeostasis,lipid metabolism,redox stabilization,neuronal remodeling,and functional recovery after trauma.In this review,we summarized the latest molecular mechanisms of ferroptosis and current research on ferroptosis,especially its role in the progression of cerebral ischemia,cerebral hemorrhage,traumatic brain injury and other acute brain injury.These findings will provide evidence for further understanding the pathogenesis of brain injury and searching new targets for the treatment of brain injury.