血清白细胞介素-8和恶性肿瘤相关生长因子在颅内肿瘤术后患者中的价值

Significance of serum interleukin-8 and tumor-specific growth factor in postoperative patients with intracranial tumors

目的探讨颅内肿瘤术后患者的血清白细胞介素-8(IL-8)、恶性肿瘤相关生长因子(TSGF)的应用价值及与颅内感染的相关性。方法选取2019年1月至2021年12月间西安市红会医院收治的82例颅内肿瘤患者纳入观察组,所有患者均采用手术治疗,同时选择进行体检的82例健康者纳入对照组。两组参与研究者均检测血清IL-8和TSGF,比较两组的血清IL-8、TSGF水平。针对颅内肿瘤手术患者的术后情况加以分析,按是否出现颅内感染作为分组标准,分为感染者和未感染者,对比感染者、未感染者的IL-8、TSGF水平,并分析IL-8、TSGF与颅内感染的相关性。结果观察组患者的血清IL-8、TSGF均高于对照组,差异均有统计学意义(均P<0.05)。感染者血清IL-8、TSGF水平均高于未感染者,差异均有统计学意义(均P<0.05)。颅内不同程度感染者IL-8、TSGF水平比较,差异有统计学意义(P<0.05),其中,轻度感染者IL-8、TSGF均低于中度与重度感染者,而中度感染者IL-8、TSGF水平均低于重度感染者,差异均有统计学意义(均P<0.05)。血清IL-8、TSGF与颅内肿瘤患者术后颅内感染程度呈正相关关系,差异均有统计学意义(均P<0.05)。结论为颅内肿瘤手术后患者开展血清IL-8、TSGF水平检测,可以评估其病情,同时可了解患者术后是否出现颅内感染,评估颅内感染的严重程度,故可以将其作为颅内肿瘤患者的常规临床参考指标。

Objective To analyze the significance of serum interleukin-8(IL-8)and tumor-specific growth factor(TSGF)and the relationship with intracranial infection in patients with intracranial tumors after operation.Methods Eighty-two patients with intracranial tumors were selected at Xi’an Red Cross Hospital from January 2019 to December 2021 and were included in an observation group.All of them underwent surgical treatment.At the same time,82 healthy individuals who underwent physical examination at the same hospital were selected and included in a control group.Serum IL-8 and TSGF were tested in the participants in the two groups,and the serum IL-8 and TSGF levels were compared between the two groups.The postoperative conditions of patients with intracranial tumors were analyzed.According to whether there was intracranial infection,they were divided into infected patients and uninfected patients.The levels of IL-8 and TSGF were compared between infected and uninfected patients,and the correlation between IL-8 and TSGF and intracranial infection was analyzed.Results The levels of serum IL-8 and TSGF were significantly higher in the observation group than in the control group(all P<0.05).The levels of serum IL-8 and TSGF were significantly higher in the infected patients than in the uninfected patients(all P<0.05).There were significant differences in the levels of IL-8 and TSGF among patients of different degrees intracranial infection(all P<0.05).The levels of IL-8 and TSGF in patients with mild infection were significantly lower than those in patients with moderate and severe infection,and the levels of IL-8 and TSGF in patients with moderate infection were significantly lower than those in patients with severe infection(all P<0.05).Serum IL-8 and TSGF were positively associated with the degree of postoperative intracranial infection in patients with intracranial tumors(all P<0.05).Conclusion The detection of serum IL-8 and TSGF levels can evaluate patients’condition in patients undergoing surgery for intracranial tumor.At the same time,the detection of serum IL-8 and TSGF can understand whether the patient has intracranial infection after operation,and the severity of intracranial infection can be evaluated through this examination.Therefore,it can be used as a routine clinical reference index for patients with intracranial tumors.