肝细胞癌血清长链非编码RNA LINC00205和bFGF表达水平与预后的相关性

Correlation between the expression levels of serum long non-coding RNA LINC00205 and bFGF and prognosis in hepatocellular carcinoma

目的探讨肝细胞癌血清长链非编码RNA(lncRNA)LINC00205和碱性成纤维细胞生长因子(bFGF)表达水平与预后的相关性。方法选取2018年4月至2021年1月间西安大兴医院诊治的66例肝细胞癌患者作为肝细胞癌组,同期选择体检的66例健康人群作为健康组。检测两组血清lncRNALINC00205和bFGF表达水平,随访肝细胞癌患者的预后并进行相关性分析。结果肝细胞癌组的血清lncRNALINC00205和bFGF表达水平高于健康组,差异有统计学意义(P<0.05)。肝细胞癌患者随访到2021年8月1日,平均随访时间(18.32±0.82)个月,生存46例,死亡20例,致死率为30.3%。死亡患者的血清lncRNALINC00205和bFGF表达水平高于生存患者,差异有统计学意义(P<0.05)。在肝细胞癌患者中,Spearman分析显示,预后与lncRNALINC00205和bFGF存在相关性,差异有统计学意义(P<0.05)。多因素Cox比例风险模型分析显示,lncRNALINC00205、bFGF为导致患者预后死亡的重要因素,差异有统计学意义(P<0.05)。结论肝细胞癌患者多表现血清lncRNALINC00205和bFGF的高表达,与患者的预后存在相关性,也是影响患者预后的重要危险因素。

Objective To investigate the correlation between the expression levels of serum long non-coding RNA(lncRNA) LINC00205 and basic fibroblast growth factor(bFGF) and prognosis in hepatocellular carcinoma. Methods From April 2018 to January 2021, 66 patients with hepatocellular carcinoma who were diagnosed and treated at Xi’an Daxing Hospital were selected and included in a hepatocellular carcinoma group, and 66 healthy individuals who received physical examination at this hospital during the same period were selected and included in a healthy group. Serum lncRNA LINC00205 and bFGF expression level were detected in the two groups. Patients with hepatocellular carcinoma were followed up for the prognosis and the correlation was analyzed. Results The expression levels of serum lncRNA LINC00205 and bFGF were higher in the hepatocellular carcinoma group than in the healthy group(all P<0.05). Hepatocellular carcinoma patients were followed up until August 1, 2021, with the average follow-up time were 18.32±0.82 months. Forty-six patients survived and 20 patients died. The mortality rate were 30.3%. The expression levels of serum lncRNA LINC00205 and bFGF in dead patients were higher than in surviving patients(all P<0.05). In patients with hepatocellular carcinoma, Spearman analysis showed that the prognosis was associated with lncRNA LINC00205 and bFGF(all P<0.05). Multivariate Cox proportional hazard model analysis showed that lncRNA LINC00205 and bFGF were important factors leading to the prognosis of death(all P<0.05). Conclusion Patients with hepatocellular carcinoma often show high levels of serum lncRNA LINC00205 and bFGF, which are associated with the prognosis of patients, and are also important risk factors affecting the prognosis of patients.