新生儿TORCH项目检测的意义

Significance of TORCH detection in neonates

目的统计黑龙江地区新生儿TORCH优生项目检测结果,分析和探讨优生项目检测在新生儿生长发育中的意义。方法收集2020年1月—2022年8月送检至黑龙江迪安医学检验所有限公司的564份新生儿血液样本,其中男性293例,女性271例;根据日龄不同分为0~7 d组(466例)、8~14 d组(38例)、15~21 d组(22例)、22~28 d组(38例)。采用电化学发光方法(ECL)检测单纯疱疹病毒Ⅰ免疫球蛋白G(HSV1-IgG)、单纯疱疹病毒ⅡIgG(HSV2-IgG)、风疹病毒IgM(RV-IgM)、风疹病毒IgG(RV-IgG)、巨细胞病毒IgM(CMV-IgM)、巨细胞病毒IgG(CMV-IgG)、刚地弓形虫IgM(TOX-IgM)、刚地弓形虫IgG(TOX-IgG),统计分析不同日龄组新生儿的各指标阳性率、检测结果分布以及意义。结果8个项目结果统计分析显示,不同日龄组CMV-IgM检测结果比较差异有统计学意义,8~14 d和22~28 d组的阳性率分别为2.6%和5.3%,0~7 d组和15~21 d组的阳性率均为0%;统计另外7个项目结果,各日龄组差异均显示无统计学意义。所有受检新生儿中,HSV1-IgG,RV-IgG和CMV-IgG项目的阳性率分别为76.6%、90.1%和96.2%,HSV2-IgG的阳性率为16.2%,其余4项阳性率均<5%。新生儿中可存在两种以上病原体标志物阳性。结论新生儿TORCH项目阳性率较高,分析原因可能与母亲的既往感染或疫苗接种产生免疫性抗体有关,同时发现有多种病原体抗体合并阳性的现象存在。新生儿TORCH病原体感染易造成器官损伤,因此检出阳性结果时不容忽视,应结合临床体征及早进行诊断并给予治疗。

Objective To analyze and discuss the significance of eugenics indexes in the process of neonatal growth by the statistics on the results of neonatal TORCH eugenic items.Methods The 564 blood samples of newborns which were sent to Heilongjiang Dean Medical Laboratory Co.,Ltd.from January 2020 to August 2022 were collected,including 293 males and 271 females.According to different ages,they were divided into 0-7 days group(466 samples),8-14 days group(38 samples),15-21 days group(22 samples)and 22-28 days group(38 samples).The herpes simplex virusⅠimmunoglobulin G(HSV1-IgG),herpes simplex virusⅡIgG(HSV2-IgG),rubella virus IgM(RV-IgM),rubella virus IgG(RV-IgG),cytomegalovirus IgM(CMV-IgM),cytomegalovirus IgG(CMV-IgG),Toxoplasma gondii IgM(TOX-IgM)and Toxoplasma gondii IgG(TOX-IgG)were detected by electrochemiluminescence(ECL).Then the positive rate,distribution and significance of each index in different age groups were statistically analyzed.Results Statistical analysis of the results of 8 items showed that there were significant differences in the results of CMV-IgM in different age groups,the positive rates of 8-14 days and 22-28 days groups were 2.6%and 5.3%,and the positive rates of 0-7 days and 15-21 days groups were both 0%.The other 7 items had no significant difference in the results.The positive rates of HSV1-IgG,RV-IgG and CMV-IgG were 76.6%,90.1%and 96.2%,that of HSV2-IgG was 16.2%,and those of the other four items were all<5%.There were positive results of two indicators in neonates.Conclusions The high positive rate of neonatal TORCH items may be related to the mother's previous infection or vaccination to produce immune antibodies.At the same time,it is found that a variety of pathogens are combined positive.The neonatal TORCH pathogens might cause organ damage.The positive results should not be ignored,and early diagnosis and treatment should be carried out in combination with clinical practice.