摘要
报道了一种布朗斯特酸/可见光氧化还原接力催化合成喹唑啉(硫)酮的方法.在温和的反应条件下,原料2-氨基苯乙酮和异(硫)氰酸酯先后经历了布朗斯特酸催化的[4+2]环化反应和光催化的碳-碳键断裂反应,得到各种不同取代的喹唑啉-2,4-二酮和喹唑啉-2-硫酮-4-酮.该合成方法具有能源和溶剂绿色、无金属催化剂、起始原料简单以及以空气作为绿色氧化剂等特点.
A relay Br?nsted acid/visible-light photoredox catalysis strategy for the synthesis of quinazolin(thi)ones is developed. In this procedure, 2-aminoacetophenones and iso(thio)cyanates undergo Br?nsted acid catalyzed [4+2] annulation,followed by photocatalyzed C—C bond cleavage reaction. A wide range of diversely substituted quinazoline-2,4-diones and quinazoline-2-thione-4-ones were synthesized under mild conditions. The protocol features eco-benign energy source and solvent, metal-free catalysts, simple starting materials and air as green oxidant.
作者
潘振涛
刘彤
马永敏
颜剑波
王亚军
Zhentao Pan;Tong Liu;Yongmin Ma;Jianbo Yan;Ya-Jun Wang(College of Biotechnology and Bioengineering,Zhejiang University of Technology,Hangzhou 310014;School of Pharmaceutical and Chemical Engineering,Taizhou University,Jiaojiang,Zhejiang 318000;Zhejiang Lepu Pharmaceutical Co.Ltd.,Jiaojiang,Zhejiang 318000)
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2022年第9期2823-2831,共9页
Chinese Journal of Organic Chemistry
基金
中国博士后科学基金(No.2021M692859)
浙江省自然科学基金(Nos.LQ21B060001,LZ21B060002)
国家自然科学基金面上(No.22178318)资助项目.
关键词
接力催化
可见光催化
绿色合成
喹唑啉酮
relay catalysis
visible-light catalysis
green synthesis
quinazolinone
