摘要
对深海来源真菌Talaromyces indigoticus FS688进行化学成分研究,从中发现了3个新的聚酮类化合物以及5个已知化合物,其化学结构是通过综合的波谱分析得以确定,同时其绝对构型是通过理论电子圆二色谱(ECD)计算确定.其中,5-甲基六氢呋喃[2,3-b]呋喃-2-基-乙烷-1-醇(2)对所测试的4株人体肿瘤细胞株(SF-268,MCF-7,Hep G-2和A549)表现出显著的细胞毒活性, IC_(50)介于0.18~0.53μmol/L之间.
The chemical investigation of the deep-sea-derived fungus Talaromyces indigoticus FS688 led to the isolation of three new polyketides together with five known compounds. Their structures were determined by comprehensive spectroscopic analysis and the absolute configurations were evaluated by theoretical electrostatic circular chroism(ECD) calculations.Among them, 5-methylhexahydrofuro[2,3-b]furan-2-yl-ethan-1-ol(2) exhibited significant cytotoxicity against the four tested human tumor cell lines(SF-268, MCF-7, HepG-2 and A549) with the IC_(50) values in the range of 0.18~0.53 μmol/L.
作者
李明琼
黄惠彬
陈玉婵
李赛妮
刘昭明
王彦林
章卫民
高晓霞
Mingqiong Li;Huibin Huang;Yuchan Chen;Saini Li;Zhaoming Liu;Yanlin Wang;Weimin Zhang;Xiaoxia Gao(School of Pharmacy,Guangdong Pharmaceutical University,Guangzhou 510006;Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application,State Key Laboratory of Applied Microbiology Southern China,Institute of Microbiology,Guangdong Academy of Sciences,Guangzhou 510070;Key Laboratory of Ocean and Marginal Sea Geology,Innovation Academy of South China Sea Ecology and Environmental Engineering,South China Sea Institute of Oceanology,Chinese Academy of Sciences,Guangzhou 510301)
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2022年第9期2975-2980,共6页
Chinese Journal of Organic Chemistry
基金
国家自然科学基金(Nos.41906106,31272087)
广东省海洋经济发展专项基金(No.GDNRC[2021]054)
国家自然科学基金委员会共享航次计划(Nos.41849906,41949906)资助项目
该航次(航次编号:NORC2019-06,NORC2020-06)由“嘉庚”号科考船实施.
