手性膦催化的氮杂环合成研究进展

Progress in Synthesis of Nitrogen Heterocycles Catalyzed by Chiral Phosphine

手性氮杂环是一类重要的有机分子,这类骨架广泛存在于药物、农药以及许多具有生物活性的天然产物分子中,手性含氮杂环的合成是有机合成化学中的重要研究领域,有机催化反应是合成氮杂环的重要方法,在这些方法中,手性有机膦催化的氮杂环的合成被证明是一个实用且强大的方法.对近年来手性膦催化的氮杂环的合成反应进行了综述,并对该领域的发展方向进行了展望.

Chiral aza-heterocycles are important molecular skeletons of organic chemistry,which are extensively found in pharmaceuticals,pesticides and biologically active natural products.As a significant organic chemistry research filed,the development of efficient novel synthetic methods of them has been a challenge.Among these strategies for the synthesis of aza-heterocycles compounds,chiral phosphine organocatalysis provides a practical and powerful platform.The recent progress in synthesis of chiral nitrogen heterocycles catalyzed by chiral phosphine is summarized,and the development of this field is also prospected.