摘要
基于两步模块化合成,制备了一类新型的联芳基轴手性膦-烯配体.该类配体在钯催化的吲哚不对称烯丙基烷基化反应中表现出很好的催化活性和不对称诱导效果.在最优的反应条件下,能以高达95%的收率和96%的对映选择性生成一系列手性的烯丙基吲哚化合物.
A new type of axially chiral phosphine-alkene ligands have been developed via a two-step modular synthesis for Pd-catalyzed asymmetric allylic alkylation of indoles. Under optimized reaction conditions, a series of chiral allylindole products were obtained in generally high yields(up to 95%) and excellent enantioselectivities(up to 96% ee).
作者
贾仕虎
陈思元
刘泽水
程鸿刚
周强辉
Jia Shihu;Chen Siyuan;Liu Zeshui;Cheng Honggang;Zhou Qianghui(College of Chemistry and Molecular Sciences,Wuhan University,Wuhan 430072;Green Catalysis Center,College of Chemistry,Zhengzhou University,Zhengzhou 450001;The Institute for Advanced Studies,Wuhan University,Wuhan 430072)
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2022年第10期3373-3381,共9页
Chinese Journal of Organic Chemistry
基金
国家自然科学基金(Nos.21871213,22071189)
中央大学基础研究基金(No.2042021kf0214)资助项目。
关键词
钯催化
膦-烯配体
吲哚
烯丙基烷基化
不对称催化
palladium catalysis
phosphine-alkene ligand
indole
allylic alkylation
asymmetric catalysis
