中国西部地区近20年肝棘球蚴病的贝叶斯单臂meta分析

Prevalence of hepatic echinococcosis in Western China in recent 20 years:A Bayesian single-arm meta-analysis

目的系统评价中国西部地区近20年肝棘球蚴病的流行情况。方法计算机检索PubMed、EMbase、VIP、WanFang Data和CNKI数据库,搜集中国西部地区肝棘球蚴病发生情况的横断面研究,检索时限均为建库至2021年12月。由2名研究者独立筛选文献、提取资料并评价纳入研究的偏倚风险后,采用R软件(4.1.2)进行Meta分析。结果共纳入40个研究,调查人群798982人。贝叶斯Meta分析结果显示我国西部6省被调查流行病区肝棘球蚴病的总发病率为3.31%(95%HPD:2.34%~4.53%)。甘肃流行病区合并的总发病率为1.51%(95%HPD:0.14%~5.48%);宁夏流行病区合并的总发病率为4.43%(95%HPD:1.22%~11.17%);新疆流行病区合并的总发病率为4.04%(95%HPD:0.09~25.40%);青海流行病区合并的总发病率为3.46%(95%HPD:2.23%~5.11%);四川流行病区合并的总发病率为7.25%(95%HPD:3.15%~14.03%);西藏流行病区合并的总发病率为0.97%(95%HPD:0.72%~1.26%)。结论近20年来我国西部地区肝棘球蚴病的流行和职业、地理位置、性别、民族等因素相关联,需要根据疾病的特点对重点人群做好疾病的预防教育、宣传和诊疗工作。

Objective To systematically evaluate the prevalence of hepatic echinococcosis in Western China in recent 20 years.Methods Computer research of PubMed,EMBASE,VIP,Wanfang Data and CNKI databases were performed to collect the cross-sectional study of the incidence of hepatic echinococcosis in Western China from inception to December 2021.Two researchers independently screened the literature,extracted data and evaluated the risk of bias included in the study.All the meta-analyses were generated by R(4.1.2)software.Results A total of 40 studies were included with 798982 subjects.Bayesian meta-analysis of showed that the overall prevalence of hepatic echinococcosis in the six investigated provinces of Western China was 3.31%(95%HPD:2.34%-4.53%).The overall prevalence of Gansu’s epidemic area was 1.51%(95%HPD:0.14%-5.48%).The overall prevalence of Ningxia’s epidemic area was 4.43%(95%HPD:1.22%-11.17%).The overall prevalence of Xinjiang’s epidemic area was 4.04%(95%HPD:0.09%-25.40%).The overall prevalence of Qinghai’s epidemic area was 3.46%(95%HPD:2.23%-5.11%).The overall prevalence of Sichuan’s epidemic area was 7.25%(95%HPD:3.15%-14.03%).The overall prevalence of Tibet’s epidemic area was 0.97%(95%HPD:0.72%-1.26%).Conclusion In the past 20 years,the prevalence of hepatic echinococcosis in the epidemic areas in Western China has spatial distribution characteristics.Besides,alveolar hepatic echinococcosis is the main disease in Tibet,Gansu and Xinjiang,while cystic hepatic echinococcosis is the main disease in Ningxia,Qinghai and Sichuan.The incidence rate is related to occupation,gender,nationality and other factors.It is necessary to do a good job in disease prevention education,publicity and diagnosis and treatment for key populations according to the characteristics of the disease.