Affibody分子在生物技术和医学应用中的研究进展

Research progress of Affibody molecule in biotechnology and medical application

Affibody分子,也被称为亲和体或者多肽适体探针,属于非抗体蛋白质的骨架结构。因其区别于一般抗体分子的结构特征,具有相对分子质量小、靶向性高、亲和力强,以及结构稳定、耐高温、可化学修饰等优势,因此Affibody的应用研究与发展迅速,已广泛应用于诊断和治疗等领域。对Affibody技术的最新进展,尤其是已经进行转化的研究进行重点综述。

Affibody,also known as affibodies or peptide aptamer probes,belongs to the backbone of non-antibody proteins.Because it is different from the structural characteristics of general antibody molecules,it has the advantages of small size,high targeting,strong affinity,stable structure,high temperature resistance,ease of engineering,etc.Therefore,the application research and development of Affibody is rapid and has been widely used.In the fields of diagnosis and therapy,it can be used as a tool for molecular recognition in diagnostic and therapeutic applications,and the accumulated clinical evidence shows that Affibody molecules are effective and safe in humans.This article will focus on the recent progress of Affibody technology,especially the translational studies.