肝癌患者肝移植术后复发与血清内皮素和肌腱蛋白-C水平的相关性研究

Correlation of serum endothelin and tenascin-C levels in patients with liver cancer recurrence after liver transplantation

目的探讨与研究肝癌患者肝移植术后复发与血清内皮素和肌腱蛋白-C水平的相关性。方法采用回顾性研究,选取2017年2月到2021年4月在新疆医科大学第一附属医院进行肝移植的肝癌患者63例作为研究对象。所有患者随访到2022年6月1日,平均随访时间为(24.05±2.63)个月,根据有无复发分为复发组13例和未复发组50例。详细记录两组患者肝移植指标,包括供肝热缺血时间、冷缺血时间、手术时间等;同时记录两组患者移植前1 d的血清内皮素和肌腱蛋白-C含量;分析移植前血清内皮素、肌腱蛋白-C含量与移植后复发的相关性;并分析影响肝癌患者肝移植术后复发的因素。结果复发组的供肝热缺血时间、冷缺血时间、手术时间与未复发组比较,差异均无统计学意义(P>0.05)。复发组的移植前1 d的血清内皮素和肌腱蛋白-C含量为(145.37±10.42)、(12.58±0.35)pg/mL,均显著高于未复发组[(45.20±4.13)、(4.21±0.32)pg/mL],差异均有统计学意义(P<0.05)。在63例患者中,Spearsman分析显示移植前血清内皮素、肌腱蛋白-C含量与移植后复发存在相关性(r=0.644、0.692,P<0.05)。移植前血清内皮素、肌腱蛋白-C含量为导致肝癌患者肝移植术后复发的重要因素(P<0.05)。结论肝癌肝移植术后复发比较常见,术后复发患者在移植前多伴随有血清内皮素和肌腱蛋白-C的高表达,两者的高表达与术后复发存在相关性,也是导致术后复发的重要因素。

Objective To retrospectively investigate the correlation between recurrence and serum endothelin and tendinin-C levels in patients with liver cancer after liver transplantation.Methods From February 2017 to April 2021,63 cases of patients with liver cancer who underwent liver transplantation in the First Affiliated Hospital of Xinjiang Medical University were retrospectively selected as the research subjects.All patients were followed up until June 1,2022,with the average follow-up time of(24.05±2.63)months.According to whether there was recurrence or not,13 patients were divided into recurrence group and 52 patients were divided into non recurrence group.The parameters of liver transplantation in two groups were recorded in detail,including warm ischemia time,cold ischemia time,operation time,etc;at the same time,the levels of serum endothelin and tendon protein-C were recorded 1 day before transplantation in the two groups;the correlation between the levels of serum endothelin and tendon protein C before transplantation and the recurrence after transplantation was analyzed;the factors influencing the recurrence of liver cancer after liver transplantation were analyzed.Results There was no significant difference in warm ischemia time,cold ischemia time and operation time between the recurrent group and the non recurrent group(P>0.05).The levels of serum endothelin and tenascin-C in the recurrence group 1 day before transplantation were(145.37±10.42)and(12.58±0.35)pg/mL,which were significantly higher than those in the non-recurrence group[(45.20±4.13)and(4.21±0.32)pg/mL],the differences were statistically significant(P<0.05).In the 63 patients,Spearsman analysis showed that serum endothelin and tenascin-C levels before transplantation were correlated with recurrence after transplantation(r=0.644,0.692,P<0.05).The levels of serum endothelin and tenascin-C before transplantation were important factors leading to the recurrence of liver cancer patients after liver transplantation(P<0.05).Conclusion The recurrence of liver cancer after liver transplantation is relatively common.Patients with postoperative recurrence are mostly accompanied by high expression of serum endothelin and tenascin-C before transplantation.important factor in recurrence.