摘要
L-谷氨酸是目前产量最大的氨基酸品种,也是我国生产规模最大的生物发酵产品。随着合成生物技术以及新型生产装备和技术的发展,国内L-谷氨酸菌种和生产技术近年来取得了明显的提升。本文从L-谷氨酸产业的现状分析和关键技术创新需求的角度出发,概述了L-谷氨酸菌种和生产技术的研究进展,介绍了近年来L-谷氨酸生产关键技术的创新开发和产业应用的进展。
The fermentative production of L-glutamate is by far the largest among the amino acids commercially produced.L-glutamate is also the largest fermentation product in China in terms of the production scale.With the rapid development in synthetic biotechnology,production equipment and process technologies,the performance of industrial strains and the production technology of L-glutamate have been advanced remarkably in recent years.By analyzing the current situation of L-glutamate industry and the demand for innovation of key technologies,this review summarizes the research progress of L-glutamate production strains and technologies,as well as the development of other key technologies in L-glutamate production and industrial application.
作者
李学朋
陈久洲
张东旭
李树标
王小平
吕金东
周敬
许志颖
郑平
孙际宾
LI Xuepeng;CHEN Jiuzhou;ZHANG Dongxu;LI Shubiao;WANG Xiaoping;LÜ Jindong;ZHOU Jing;XU Zhiying;ZHENG Ping;SUN Jibin(Key Laboratory of Bio-Fermentation Energy Saving and Environmental Protection Technology Enterprise of Inner Mongolia Autonomous Region,Inner Mongollia Fufeng Biotechnologies Co.Ltd.,Huhot 010030,Inner Mongolia,China;Key Laboratory of Systems Microbial Biotechnology,Tianjin Institute of Industrial Biotechnology,Chinese Academy of Sciences,Tianjin 300308,China;National Technology Innovation Center of Synthetic Biology,Tianjin 300308,China;Hulunbeier Northeast Fufeng Biotechnologies Co.Ltd.,Hulunbuir 162650,Inner Mongolia,China)
出处
《生物工程学报》
CAS
CSCD
北大核心
2022年第11期4343-4351,共9页
Chinese Journal of Biotechnology
基金
国家重点研发计划(2019YFA0904900)
国家自然科学基金(32000023)。
关键词
L-谷氨酸
谷氨酸棒杆菌
工业菌种
氨基酸生产
L-glutamate
Corynebacterium glutamicum
industrial strains
amino acid production
