3D打印骨组织支架孔隙结构对支架性能影响的研究进展

Research progress in effect of pore structure on performance of 3D printed bone tissue scaffolds

从骨组织工程支架孔隙形状、孔径大小、孔隙率、表面粗糙度、连接通路5方面对支架孔的微观结构的研究现状进行了综述。发现梯度结构的支架孔隙形状更接近天然骨,粗糙的表面可以改善细胞的黏附和增殖,非正交连接通路的内部结构可以为后期骨再生提供一个动态的生长空间。

This paper reviewed the research status of the microstructure of scaffold pores from five aspects,including the pore shape,pore size,porosity,surface roughness,and connection pathways of bone tissue engineering scaffolds.The pore shape of the scaffold with a gradient structure was found to be closer to those of the natural bone.The rough surface can improve the cell adhesion and proliferation of the scaffolds,and the internal structure of the non⁃orthogonal connec⁃tion pathway can provide a dynamic growth space for later bone regeneration.