国医大师潘敏求治疗结直肠癌的用药规律分析

Treatment of colorectal cancer by TCM Master PAN Minqiu

目的探讨国医大师潘敏求治疗结直肠癌的用药规律,为临床用药提供参考。方法收集整理潘教授治疗结直肠癌的医案,将处方录入Excel 2010建立数据库,采用古今医案云平台(V2.3.5)进行单味中药的频次分析、中药属性频次分析、药物归经频次统计、关联规则和聚类分析,使用Excel进行药物功效频次统计。结果纳入的300首方剂中,共使用中药138味,累计使用频次5620次,共获得甘草、白术、黄芪、茯苓、白花蛇舌草、女贞子、菟丝子、人参、枸杞子、莪术等15味核心药物,药味多甘、苦、辛,主要归脾、肝、肺经。关联规则分析获得黄芪-白术、黄芪-茯苓、白术-茯苓等50组核心药对。聚类分析获得C1(莪术、重楼)、C2(茯苓、甘草、白术、黄芪、白花蛇舌草)等3个聚类方。结论国医大师潘敏求治疗结直肠癌多从瘀、毒、虚入手,采用健脾益气、清热解毒化瘀治法,擅长攻补兼施,取得较好临床疗效。

Objective To investigate the medication rules of TCM Master PAN Minqiu in the treatment of colorectal cancer,and to provide a reference for clinical medication.Methods The medical cases of Professor PAN Minqiu in the treatment of colorectal cancer were collected and sorted;the prescriptions were entered into Excel 2010 to establish a database;the frequency analysis of single-flavor Chinese medicine,the frequency analysis of Chinese medicine attributes,the frequency statistics of drug attribution,correlation rules and cluster analysis were carried out using Ancient and Modern Medical Case Cloud V2.3;the frequency statistics of drug efficacy were carried out using Excel.Results Among the 300 cases of prescriptions included,a total of 138 flavors of Chinese medicine were used;the cumulative frequency of use was 5620 times;15 core drugs such as Gancao(Radix Et Rhizoma Glycyrrhizae),Baizhu(Rhizoma Atractylodis Macrocephalae),Huangqi(Radix Astragali),Fuling(Poria),Baihuasheshecao(Herba Hedyotis Diffusae),Nvzhenzi(Fructus Ligustri Lucidi),Tusizi(Semen Cuscutae),Renshen(Radix Et Rhizoma Ginseng),Gouqi(Fructus Lycii),and Ezhu(Rhizoma Curcumae).The medicinal tastes were mainly sweet,bitter,and pungent.The medicines were mainly attributed to the spleen,liver and lung meridians.We analyzed and obtained 50 core drug pairs such as Huangqi(Radix Astragali)-Baizhu(Rhizoma Atractylodis Macrocephalae),Huangqi(Radix Astragali)-Fuling(Poria),and Baizhu(Rhizoma Atractylodis Macrocephalae)-Fuling(Poria)by correlation rules.Three clustering parties were obtained,including C1[Ezhu(Rhizoma Curcumae),Chonglou(Rhizoma Paridis)],C2[Fuling(Poria),Gancan(Radix Et Rhizoma Glycyrrhizae),Baizhu(Rhizoma Atractylodis Macrocephalae),Huangqi(Radix Astragali),and Baihuasheshecao(Herba Hedyotis Diffusae)].Conclusion Professor PAN Minqiu,the TCM Master,starts with stasis,poison and weakness in the treatment of colorectal cancer,adopts the treatment method of"strengthening the spleen and benefiting qi,clearing heat,detoxifying and dissolving stasis",and is good at reinforcing healthy qi and removing pathogenic factors simultaneously.