生长激素与肠道菌群相关性研究进展

Research progress on the correlation between growth hormone and gut microbiota

人生长激素(hGH)由垂体前叶嗜酸性粒细胞合成,可通过胰岛素样生长因子-1(IGF-1)对生长和代谢发挥作用。GH的缺乏或分泌不足导致的矮小症称为生长激素缺乏症(GHD),其具体病因及确切机制仍未完全阐释清楚。近年来,随着对肠道微生物菌群的认识及研究的深入,发现GH-IGF-1轴与肠道菌群存在相关性。文章就GH-IGF-1轴与肠道菌群关系的研究进行了阐述。

Human growth hormone(hGH),synthesized by eosinophils in the anterior pituitary gland,exerts effects on growth and metabolism through insulin-like growth factor-1(IGF-1).Short stature caused by GH deficiency or insufficient secretion is called growth hormone deficiency(GHD),but its specific etiology and exact mechanism have not been fully explained.In recent years,with the in-depth understanding and research of gut microbiota,it has been found that the GH-IGF-1 axis is correlated with gut microbiota.This article reviews the research on the relationship between the GH-IGF-1 axis and the gut microbiota.