非小细胞肺癌增强CT影像特征与临床病理特征及预后的关系

Relationship Between Enhanced CT and Clinicopathological Features and Prognosis of Non-small Cell Lung Cancer

目的探讨非小细胞肺癌(NSCLC)增强CT影像特征与临床病理特征及预后的关系,为临床诊治NSCLC提供参考。方法选取78例NSCLC患者作为研究对象,所有患者均接受增强CT扫描。统计增强CT扫描结果,分析增强CT强化程度与患者临床病理特征间关系,并分析增强CT参数与NSCLC患者预后的关系,最后开展COX回归分析获取影响NSCLC患者预后的独立危险因素。结果78例NSCLC患者增强CT扫描结果:43例轻度强化,35例明显强化;32例肿瘤直径≤3 cm,18例肿瘤直径>3~7 cm,28例肿瘤直径≥7 cm;33例淋巴结≥1 cm,45例淋巴结<1 cm;10例无淋巴结肿大,31例肺门淋巴结肿大,37例纵隔淋巴结肿大。增强CT明显强化患者与轻度强化患者间肿瘤分化程度、淋巴结转移及TNM分期相比,差异有统计学意义(P<0.05)。经长期随访,78例NSCLC患者存活55例,3年生存率为70.51%(55/78);不同CT增强、肿瘤大小、淋巴结大小、淋巴结肿大NSCLC患者3年生存率相比,差异有统计学意义(P<0.05);肿瘤大小、CT强化程度、淋巴结肿大、淋巴结大小、TNM分期及淋巴结转移为影响NSCLC患者预后的独立危险因素(P<0.05)。结论NSCLC患者增强CT影像特征与临床病理特征及预后关系密切,尽早采用增强CT检查明确强化程度、肿瘤大小、淋巴结肿大等信息,能够良好评估患者预后,为临床治疗提供参考。

Objective To explore the relationship between enhanced CT and clinicopathological features and prognosis of non-small cell lung cancer(NSCLC),so as to provide reference for clinical diagnosis and treatment of NSCLC.Methods 78 patients with NSCLC were selected as the research object.All patients underwent enhanced CT scanning.The results of enhanced CT scanning were counted,the relationship between the degree of enhanced CT and the clinicopathological characteristics of patients was analyzed,and the relationship between enhanced CT parameters and the prognosis of NSCLC patients was analyzed.Finally,Cox regression analysis was carried out to obtain the independent risk factors affecting the prognosis of NSCLC patients.Results 78 patients with NSCLC showed mild enhancement in 43 cases and significant enhancement in 35 cases;32 cases had tumor diameter≤3 cm,18 cases had tumor diameter:3~7 cm,28 cases had tumor diameter≥7 cm;33 lymph nodes≥1 cm,45 lymph nodes<1cm;There were no lymphadenopathy in 10 cases,hilar lymphadenopathy in 31 cases and mediastinal lymphadenopathy in 37 cases;There were significant differences in tumor differentiation,lymph node metastasis and TNM stage between patients with significantly enhanced CT and patients with mild enhanced CT(P<0.05);After long-term follow-up,55 of 78 patients with NSCLC survived,and the 3-year survival rate was 70.51%(55/78);The 3-year survival rate of NSCLC patients with different CT enhancement,tumor size,lymph node size and lymph node enlargement was statistically significant(P<0.05);Tumor size,CT enhancement degree,lymph node enlargement,lymph node size,TNM stage and lymph node metastasis were independent risk factors affecting the prognosis of patients with NSCLC(P<0.05).Conclusion enhanced CT is closely related to the clinicopathological features and prognosis of NSCLC patients.Early use of enhanced CT to clarify the degree of enhancement,tumor size,lymph node enlargement and other information can well evaluate the prognosis of patients and provide reference for clinical treatment.