上皮性卵巢癌并发深静脉血栓的相关影响因素分析

Analysis of Related Factors of Deep Venous Thrombosis in Patients with Epithelial Ovarian Cancer

目的探讨上皮性卵巢癌患者并发深静脉血栓(DVT)的相关影响因素,为临床防治DVT提供重要参考。方法回顾性分析72例上皮性卵巢癌患者临床资料,依据是否存在DVT分为DVT组与非DVT组,收集两组年龄、体质量指数、肿瘤类型、肿瘤分期、肿瘤分级、糖类抗原125(CA125)水平、纤维蛋白原(FIB)、血小板计数(PLT)、高血压、糖尿病、高脂血症等基础资料。先开展单因素分析,获取有差异的项目后,纳入Logistic回归分析,最终得到影响DVT发生的独立危险因素。结果72例患者,经DVT检查确诊19例,DVT发生率为26.39%(19/72);单因素分析显示,肿瘤类型、高血压、糖尿病与DVT发生无关(P>0.05);年龄、体质量指数、肿瘤分期、肿瘤分级、CA125、高脂血症、FIB、PLT与DVT发生有关(P<0.05);多因素分析显示,年龄≥60岁、体质量指数≥25 kg/m^(2)、肿瘤分期Ⅲ~Ⅳ期、肿瘤分级G3、CA125水平≥785 U/mL、有高脂血症、FIB≥4 g/L、PLT≥400×109/L为影响DVT发生的独立危险因素(P<0.05且OR>1)。结论上皮性卵巢癌患者易并发DVT,且年龄≥60岁、体质量指数≥25 kg/m^(2)、肿瘤分期Ⅲ~Ⅳ期、肿瘤分级G3等为诱发DVT的重要危险因素,临床需开展针对性防治措施,以预防DVT发生。

Objective To explore the related factors of deep venous thrombosis(DVT)in patients with epithelial ovarian cancer,and to provide important reference for clinical prevention and treatment of DVT.Methods The clinical data of 72 patients with epithelial ovarian cancer were retrospectively analyzed.They were divided into DVT group and non DVT group according to the existence of DVT.The basic data of age,body mass index,tumor type,tumor stage,tumor grade,carbohydrate antigen 125(CA125)level,fibrinogen(FIB),platelet count(PLT),hypertension,diabetes,hyperlipidemia and so on were collected.First,carry out univariate analysis to obtain the items with differences,and then incorporate them into logistic regression analysis to finally obtain the independent risk factors affecting the occurrence of DVT.Results Among the 72 patients,19 were diagnosed by DVT.The incidence of DVT was 26.39%(19/72);Univariate analysis showed that tumor type,hypertension and diabetes had no relationship with DVT(P>0.05);Age,body mass index,tumor stage,tumor grade,CA125,hyperlipidemia,FIB and PLT were related to the occurrence of DVT,and the difference was statistically significant(P<0.05);Multivariate analysis showed that age≥60 years old,body mass index≥25 kg/m 2,tumor stageⅢ~Ⅳ,tumor grade G3,CA125 level≥85 U/ml,hyperlipidemia,FIB≥4 G/L,PLT≥400×109/l was an independent risk factor for DVT(P<0.05 and or>1).Conclusion Patients with epithelial ovarian cancer are prone to DVT,and age≥60 years old,body mass index≥25 kg/m 2,tumor stageⅢ~Ⅳand tumor grade G3 are important risk factors for inducing DVT.Targeted prevention and treatment measures should be carried out in clinic to prevent DVT.