巴戟天寡糖胶囊治疗老年脑卒中后轻度抑郁患者的疗效

Application of Morinda Officinalis Oligosaccharide Capsules in Treatment of Elderly Patients with Mild Depression after Stroke

【目的】探讨巴戟天寡糖胶囊治疗老年脑卒中后轻度抑郁患者的疗效。【方法】两院收治的90例老年脑卒中后轻度抑郁患者,随机分为观察组和对照组,每组45例。对照组行艾司西酞普兰治疗,观察组在对照组基础上加用巴戟天寡糖胶囊治疗。比较两组临床疗效,治疗前后抑郁自评量表(SDS)评分、汉密顿抑郁量表(HAMD)评分、简易社会应对量表(SCSQ)评分及蒙特利尔认知功能评估量表(MoCA)评分变化和两组不良反应发生情况。【结果】观察组总有效率为95.56%(43/45),高于对照组的82.22%(37/45)(P<0.05)。两组治疗前SDS、HAMD、MoCA、SCSQ各项评分比较,差异无统计学意义(P>0.05);两组治疗后SDS、HAMD、SCSQ消极应对方式评分较治疗前降低(P<0.05),MoCA、SCSQ积极应对方式评分较治疗前升高(P<0.05);且观察组治疗后SDS、HAMD、SCSQ消极应对方式评分低于对照组(P<0.05),MoCA、SCSQ积极应对方式评分高于对照组(P<0.05)。观察组不良反应发生率为11.11%(5/45),与对照组的8.89%(4/45)比较,差异无统计学意义(P>0.05)。【结论】巴戟天寡糖胶囊治疗老年脑卒中后轻度抑郁患者疗效显著,可提高抗抑郁效果,改善患者应对方式,且不会增加不良反应发生的风险。

【Objective】To investigate the value of morinda officinalis oligosaccharide capsules in the treatment of elderly patients with mild depression after stroke.【Methods】A total of 90 elderly patients with mild depression after stroke who were admitted to two hospitals were randomly divided into two groups,with 45 cases in each group.The control group was treated with escitalopram,and the observation group was additionally treated with morinda officinalis oligosaccharide capsules on the basis of the control group.The clinical efficacy of the two groups was compared,and the scores of the Self-rating Depression Scale(SDS),Hamilton Depression Scale(HAMD),Simple Social Coping Scale(SCSQ)and Montreal Cognitive Assessment Scale(MoCA)score changes,and the incidence of adverse reactions in the two groups was observed.【Results】The total effective rate in the observation group was 95.56%,which was higher than 82.22%in the control group(P<0.05).There was no significant difference in the scores of SDS,HAMD,MoCA and SCSQ between the two groups before treatment(P>0.05).After treatment,the scores of SDS,HAMD and negative coping style in the two groups were lower than those before treatment(P<0.05),while the scores of MoCA and positive coping style were higher than those before treatment.The scores of SDS,HAMD and negative coping style of post-treatment in the observation group were lower than those in the control group(P<0.05);And the scores of MoCA and positive coping style in the observation group were higher than those in the control group(P<0.05).The incidence of adverse reactions in the observation group was 11.11%(5/45),which was not significantly different from 8.89%(4/45)in the control group(P>0.05).【Conclusion】Morinda oligosaccharide capsules have significant curative effect in the treatment of elderly patients with mild depression after stroke,which can improve the antidepressant effect,improve the coping style of patients,and will not increase the risk of adverse reactions.